{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T16:26:32Z","timestamp":1787761592352,"version":"build-2784847793"},"reference-count":15,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T00:00:00Z","timestamp":1569369600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chemical peels have become a popular modality in the treatment of acne vulgaris (AV). Mandelic acid (MA) is a new emerging peeling agent for AV owing to its antibacterial and anti\u2010inflammatory properties. Hence, it is worthwhile to evaluate the effectiveness and safety profile of this newer agent and to compare it with an older established peeling agent, salicylic acid (SA) in the treatment of AV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>Comparison between therapeutic efficacy and safety of 45% MA peel with 30% SA peel in Indian patients suffering from mild\u2010to\u2010moderate facial AV.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 50 patients suffering from mild\u2010to\u2010moderate AV were randomly divided into two groups, with one receiving 30% SA peels and the other receiving 45% MA peels at an interval of 2\u00a0weeks for six sessions. Total duration of the study was 12\u00a0weeks. Michaelsson acne scores (MAS) and clinical photographs were used to evaluate the efficacy of therapy objectively. Adverse effects of both the agents were also noted at each visit.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both agents showed almost equal efficacy in improving mild\u2010to\u2010moderate AV. Salicylic acid was found better in treating noninflammatory lesions, while MA had an upper hand in treating inflammatory lesions. Overall, there was no significant difference between the two peels in improving MAS and percentage decrease in MAS. However, adverse effects were lesser with MA peels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>About 45% MA peel was found to be equally effective as 30% SA peel in mild\u2010to\u2010moderate facial AV. However, safety and tolerability of MA peel were better than SA peel.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13168","type":"journal-article","created":{"date-parts":[[2019,9,25]],"date-time":"2019-09-25T21:12:00Z","timestamp":1569445920000},"page":"393-399","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":48,"title":["Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild\u2010to\u2010moderate acne vulgaris"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9093-6731","authenticated-orcid":false,"given":"Surabhi","family":"Dayal","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Pt. B. D. Sharma University of Health Sciences Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirti Dudeja","family":"Kalra","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Pt. B. D. Sharma University of Health Sciences Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyadarshini","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Pt. B. D. Sharma University of Health Sciences Rohtak India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,9,25]]},"reference":[{"key":"e_1_2_5_2_1","first-page":"395","article-title":"Prevalence, morbidity and cost of dermatological disease","volume":"75","author":"Kraning KK","year":"1979","journal-title":"J Invest Dermatol"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1159\/000067817"},{"key":"e_1_2_5_4_1","first-page":"1365","volume-title":"IADVL Textbook of Dermatology","author":"Vaishampayan S","year":"2015"},{"key":"e_1_2_5_5_1","first-page":"90.1","volume-title":"Rook's Textbook of Dermatology","author":"Layton AM","year":"2016"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1702493"},{"key":"e_1_2_5_7_1","first-page":"105","article-title":"An update on the management of acne vulgaris","volume":"2","author":"Keri J","year":"2009","journal-title":"Clin CosmetInvestig Dermatol"},{"key":"e_1_2_5_8_1","first-page":"17","volume-title":"Color Atlas of Chemical Peels","author":"Grimes PE","year":"2012"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2003.29384.x"},{"key":"e_1_2_5_10_1","first-page":"32","article-title":"Mandelic acid chemical peel in acne vulgaris: a boon or a bane?","volume":"14","author":"Jartarkar SR","year":"2015","journal-title":"IOSR\u2010J Dental Med Sci"},{"key":"e_1_2_5_11_1","first-page":"26","article-title":"Summary of mandelic acid for the improvement of skin conditions","author":"Taylor MB","year":"1999","journal-title":"Cosmetic Dermatology"},{"key":"e_1_2_5_12_1","first-page":"143","volume-title":"Step by Step Chemical Peels","author":"Khunger N","year":"2014"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.4103\/2542-551X.196946"},{"key":"e_1_2_5_14_1","doi-asserted-by":"crossref","first-page":"372","DOI":"10.2340\/0001555557372","article-title":"Oral zinc sulphate therapy for acne vulgaris","volume":"57","author":"Michaelsson G","year":"1977","journal-title":"Acta Derm Venereol"},{"key":"e_1_2_5_15_1","first-page":"32","article-title":"Evidence and considerations in the application of chemical peels in skin disorders and aesthetic resurfacing","volume":"3","author":"Rendon MI","year":"2010","journal-title":"Clin Aesthet Dermatol"},{"key":"e_1_2_5_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32075.x"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13168","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13168","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13168","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,21]],"date-time":"2023-08-21T19:33:03Z","timestamp":1692646383000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13168"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,9,25]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2020,2]]}},"alternative-id":["10.1111\/jocd.13168"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13168","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,9,25]]},"assertion":[{"value":"2019-02-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-08-27","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-09-25","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}