{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,11]],"date-time":"2026-02-11T14:51:45Z","timestamp":1770821505729,"version":"3.50.1"},"reference-count":23,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T00:00:00Z","timestamp":1571097600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Rosacea is a chronic\u00a0skin condition that typically\u00a0affects the face and it results in redness and inflammation. The main risk factors of this disease are <jats:italic>Demodex folliculorum<\/jats:italic>, living in the pilosebaceous units.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate\u00a0the efficacy and safty of permethrin 2.5% in combination with\u00a0tea tree oil (TTO) topical gel versus\u00a0placebo on Demodex density (Dd) and clinical manifestation\u00a0using\u00a0standard skin surface biopsy (SSSB) in rosacea patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patient\/Methods<\/jats:title><jats:p>In this double\u2010blind, randomized clinical trial, 47 papulopustular rosacea patients were enrolled, with 35 patients finishing the 12\u00a0weeks of treatment. Each patient used permethrin 2.5% with TTO on one side of the face and a placebo on the other, twice daily for 12\u00a0weeks. SSSB, photography and clinical rosacea scores according to National Rosacea Society, as well as adverse drug reaction (ADRs) were reported at the baseline, 2nd, 5th, 8th, and 12th weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 47 patients were enrolled with papulopustular rosacea, and 35 patients finished the study. The effects of permethrin 2.5% with TTO gel on mite density were significant at week 5, 8, 12 (<jats:italic>P<\/jats:italic> value\u00a0=\u00a0.001). Clinical features and global assessments showed papules, pustules and nontransient erythema had improvement in drug group after 12\u00a0weeks (<jats:italic>P<\/jats:italic> values &lt;.05). The improvement of burning and stinging and dry appearance was greater than the placebo gel (<jats:italic>P<\/jats:italic> value &lt;.05). Itching in placebo group was significantly more than other group (<jats:italic>P<\/jats:italic> value\u00a0=\u00a0.002).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Administration of permethrin 2.5% with TTO gel demonstrated good efficacy and safety in rosacea. This topical gel inhibited the inflammatory effects of rosacea and reduced Demodex mite.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13177","type":"journal-article","created":{"date-parts":[[2019,10,15]],"date-time":"2019-10-15T11:13:22Z","timestamp":1571138002000},"page":"1426-1431","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["The efficacy and safety of permethrin 2.5% with tea tree oil gel on rosacea treatment: A double\u2010blind, controlled clinical trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Elnaz","family":"Ebneyamin","sequence":"first","affiliation":[{"name":"Department of Clinical Pharmacy Faculty of Pharmacy Tehran Medical Sciences Islamic Azad University Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvin","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences Tehran 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