{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,17]],"date-time":"2026-06-17T08:49:54Z","timestamp":1781686194994,"version":"3.54.5"},"reference-count":20,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cutaneous leishmaniasis (CL) is an endemic disease of Iran and despite self\u2010healing nature of this disease and many suggested treatments, scar is usually inevitable results of the affection with this cutaneous infection. CO<jats:sub>2<\/jats:sub> laser in CL has a specific thermolysis effect on infected tissues and application of trichloroacetic acid (TCA) 50% solution for treatment of leishmaniasis scars showed promising results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate CO<jats:sub>2<\/jats:sub> laser plus TCA 50% versus CO<jats:sub>2<\/jats:sub> laser alone for treatment of CL.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>In the current report, we present 6 cases of noduloulcerative CL that were treated successfully by the combination of the continuous wave CO<jats:sub>2<\/jats:sub> laser plus topical application of TCA 50%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Five patients improved after 3\u00a0weeks of starting treatment, and 1 patient needed to repeat treatment. The scars were flat and good.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The CO<jats:sub>2<\/jats:sub> laser plus topical TCA 50% may be more effective in treatment of the cutaneous leishmaniasis and results in shorter healing time.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13181","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T10:46:14Z","timestamp":1571741174000},"page":"1367-1370","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Combination of continuous wave CO<sub>2<\/sub> laser and topical application of trichloroacetic acid 50% vs CO<sub>2<\/sub> laser alone the treatment of cutaneous leishmaniasis (A case series of 6 patients)"],"prefix":"10.1111","volume":"19","author":[{"given":"Fariba","family":"Iraji","sequence":"first","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Department of Dermatology Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ali","family":"Asilian","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Department of Dermatology Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asieh","family":"Heidari","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Department of Dermatology Isfahan University of Medical Sciences Isfahan Iran"},{"name":"Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sheila","family":"Shariat","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Department of Dermatology Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Safura","family":"Bokaie Jazi","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences Isfahan Iran"},{"name":"School of Pharmacy Isfahan university of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3201-7037","authenticated-orcid":false,"given":"Amir Hossein","family":"Siadat","sequence":"additional","affiliation":[{"name":"Skin Diseases and Leishmaniasis Research Center Isfahan University of Medical Sciences Isfahan Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"NilfroushZadehMA SadeghianG.Cutaneous leishmaniasis. 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