{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,4]],"date-time":"2026-08-04T22:54:33Z","timestamp":1785884073334,"version":"3.56.0"},"reference-count":25,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T00:00:00Z","timestamp":1571702400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Therapies for postacne scarring act through modulation of elastin and collagen, and collagen III might therefore represent a biomarker of treatment effectiveness.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and methods<\/jats:title><jats:p>Patients (n\u00a0=\u00a070) with postacne scars and individuals without scars (n\u00a0=\u00a056) were included in this case\u2010control study. Patients were treated with Dermaroller microneedling, trichloroacetic acid chemical reconstruction, punch excision, or scar subcision. Scar severity was graded immediately before and after treatment with a photographic quartile scale and the ECCA scale. Serum levels of collagen III were measured in control individuals and in patients, before treatment, 1\u00a0month after the first treatment session, and 4\u00a0months after the final session.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Circulating levels of collagen III were significantly higher in patients with postacne scarring (24.1\u00a0\u00b1\u00a012.5) before treatment than in control individuals (2.6\u00a0\u00b1\u00a00.8). Circulating levels of collagen in patients were significantly lower 4\u00a0months posttreatment (14.3\u00a0\u00b1\u00a08.1) than at baseline. The mean percentage change in serum collagen III was positively correlated with both the mean percentage improvement by photographic evaluation (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.530, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.000) and the mean percentage change in the ECCA scale (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.632, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Circulating collagen III is a biomarker for improvement of postacne scarring following different therapies.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13184","type":"journal-article","created":{"date-parts":[[2019,10,22]],"date-time":"2019-10-22T11:58:12Z","timestamp":1571745492000},"page":"1517-1521","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Effects of different therapeutic modalities for postacne scars on circulating collagen III"],"prefix":"10.1111","volume":"19","author":[{"given":"Ensaf M.","family":"Abdel\u2010Magiud","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emad A.","family":"Taha","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Radwa M.","family":"Bakr","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sahar A.","family":"Ismail","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sohair K.","family":"Sayed","sequence":"additional","affiliation":[{"name":"Department of Clinical Pathology Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamed","family":"Makboul","sequence":"additional","affiliation":[{"name":"Department of Plastic Surgery Faculty of Medicine Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzan","family":"Kamel\u2010ElSayed","sequence":"additional","affiliation":[{"name":"Foundational Medical Studies Oakland University William Beaumont School of Medicine (OUWB School of Medicine) Auburn Hills MI USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9905-7119","authenticated-orcid":false,"given":"Amira A.","family":"Abdel Motaleb","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Assiut University Assiut Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,10,22]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2007.33252.x"},{"key":"e_1_2_7_3_1","first-page":"1","article-title":"The management of atrophic acne scars: overview and new tools","volume":"51","author":"Fabbrocini G","year":"2012","journal-title":"J Clin Exp Dermatol Res"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2005.31612"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2230.2009.03291.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.185468"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12315"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jdermsci.2008.07.004"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200101000-00036"},{"key":"e_1_2_7_10_1","first-page":"36","article-title":"Microneedling therapy for atrophic acne scars: an objective evaluation","volume":"8","author":"El\u2010Domyati M","year":"2015","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2006.32220.x"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1186\/1471-5945-11-6"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1159\/000096912"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1524-4725.2000.99232.x"},{"key":"e_1_2_7_15_1","first-page":"70","article-title":"The aminoterminal propeptide of type III procollagen. 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