{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T16:52:10Z","timestamp":1790700730624,"version":"4.1.0"},"reference-count":18,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T00:00:00Z","timestamp":1574208000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma treatment is difficult due to extended treatment periods, suboptimal adherence, inconsistent results, and frequent relapses. Kojic acid has been shown to be effective in reducing melasma severity and is now increasingly used in cosmetic treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of the present study was to evaluate the effectiveness of a new cosmetic treatment for melasma at 45 and 90\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Multicenter prospective study across 20 dermatology clinics\/ambulatories. One hundred patients with mild\u2010to\u2010moderate melasma were evaluated. The primary endpoints were changes in mean modified melasma area and severity index (mMASI) score and patient\u2010reported satisfaction at 45 and 90\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The mean age of patients was 45.19\u00a0\u00b1\u00a011.5\u00a0years. Most patients were female and Caucasian. Patients presented mixed (65%), epidermal (26%), and dermal (4%) types of melasma. Triggering factors were hormonal contraception (33%), pregnancy (31%), and pharmacological treatment (11%); mean disease duration was 6.7\u00a0\u00b1\u00a06.8\u00a0years. Overall, a statistically significant decrease in mean mMASI scores was seen at 45 (2.19\u00a0\u00b1\u00a00.182 vs 3.29\u00a0\u00b1\u00a00.267, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.0001) and 90\u00a0days (1.27\u00a0\u00b1\u00a00.128 vs 3.29\u00a0\u00b1\u00a00.267, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.00001). The highest reduction in mMASI scores was observed in patients with dermal melasma. IGA scores showed a statistically significant improvement in pigmentation at 90\u00a0days (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.00001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The novel cosmetic treatment was associated with the improvement of melasma, as assessed by mMASI.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13203","type":"journal-article","created":{"date-parts":[[2019,11,20]],"date-time":"2019-11-20T11:15:35Z","timestamp":1574248535000},"page":"1684-1690","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":28,"title":["Effectiveness of a new cosmetic treatment for melasma"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3423-5038","authenticated-orcid":false,"given":"Enzo","family":"Berardesca","sequence":"first","affiliation":[{"name":"San Gallicano Dermatological Institute Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corinna","family":"Rigoni","sequence":"additional","affiliation":[{"name":"Donne Dermatologhe Italia Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandra","family":"Cant\u00f9","sequence":"additional","affiliation":[{"name":"Donne Dermatologhe Italia Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norma","family":"Cameli","sequence":"additional","affiliation":[{"name":"Donne Dermatologhe Italia Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurora","family":"Tedeschi","sequence":"additional","affiliation":[{"name":"Donne Dermatologhe Italia Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Donne Dermatologhe Italia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tiziana","family":"Laureti","sequence":"additional","affiliation":[{"name":"Department of Economics, Engineering Society and Business Organization University of Tuscia Viterbo Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2019,11,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13555-017-0194-1"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.4103\/2229-5178.142484"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2010.12.046"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2011.06.001"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1590\/abd1806-4841.20142353"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0190-9622(81)70071-9"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0733-8635(05)70150-9"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.84722"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2007.04.006"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2018.00162"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics3040036"},{"key":"e_1_2_8_13_1","unstructured":"Pigment SolutionTM Program.Product information leaflet. 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