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This study aimed to access variant <jats:styled-content style=\"fixed-case\">ALDH<\/jats:styled-content>3A2 gene coded for <jats:styled-content style=\"fixed-case\">FALDH<\/jats:styled-content> and products regulating pathogenic melanogenesis owing to increased oxidative stress and reactive oxygen species resulting in <jats:styled-content style=\"fixed-case\">DNA<\/jats:styled-content> harm in <jats:styled-content style=\"fixed-case\">SLS<\/jats:styled-content>. By turning them into fatty acids, <jats:styled-content style=\"fixed-case\">FALDH<\/jats:styled-content> avoids the accumulation of toxic fatty aldehydes. The mutation results in the accumulation of aldehyde\u2010modified lipids or fatty alcohols that may interfere with skin and brain function.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>In Nov 2018, we performed a literature search in PubMed for clinical studies, clinical trials, case reports, controlled trials, randomized controlled trials, and systemic reviews. The search terms we used were \u201c<jats:styled-content style=\"fixed-case\">SJOGREN<\/jats:styled-content>\u2010<jats:styled-content style=\"fixed-case\">LARSSON SYNDROME<\/jats:styled-content>\u201d <jats:styled-content style=\"fixed-case\">AND<\/jats:styled-content> \u201c<jats:styled-content style=\"fixed-case\">HYPERMELANNOSIS<\/jats:styled-content>\u201d <jats:styled-content style=\"fixed-case\">OR<\/jats:styled-content> \u201c<jats:styled-content style=\"fixed-case\">FALDH<\/jats:styled-content>\u201d (from 1985). The search resulted in 1,289 articles, out of these 95 articles met our inclusion exclusion criteria. Our inclusion criteria included relevant original articles relevant, critical systemic reviews, and crucial referenced articles, ex\u2010clusion criteria included duplicates and articles not published in English language.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Toxicity of long\u2010chain aldehydes to <jats:styled-content style=\"fixed-case\">FALDH<\/jats:styled-content>\u2010deficient cells owing to accumulation under the profound epidermis layer improves oxidative stress in the cell resulting in keratinocyte hyperproliferation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>While it continues to be determined whether accumulated fatty alcohol and fatty aldehydes obtained from ether glycerolipids and sphingolipids improve the susceptibility of melanocytes and their element accountable for skin hyperpigmentation to biological 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