{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T05:15:12Z","timestamp":1788326112295,"version":"build-2803163510"},"reference-count":22,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T00:00:00Z","timestamp":1574899200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Existing treatments of acne vulgaris may be complicated or elicit undesirable side effects. Therefore, new and safe therapeutic modalities are needed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We investigated the effects of a cleanser with 5\u2010aminolevulinic acid and peptides on mild to moderate acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Sixty volunteers with mild to moderate acne vulgaris (IGA grade II\u2013III) were randomly assigned to treatment or control groups of thirty respectively. Participants cleansed their faces twice a day for 8\u00a0weeks with either a cleanser with 5\u2010aminolevulinic acid and peptides (treatment) or with basic cleanser (control). The number of acne lesions (comedones, papules, pustules, and nodules), Michaelson's acne severity, and IGA were measured every 2\u00a0weeks and patient satisfaction and adverse events at week 8.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Mean number of inflammatory acne lesions in treatment group decreased from 5.9 at baseline to 4.5 at week 4 and 4.1 at week 8 (in particular, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The mean number of noninflammatory lesions in treatment group decreased from 11.4 at baseline to 8.8 at week 4 and 7.4 at week 8 (in particular, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The mean value of Michaelson's acne severity index and IGA in treatment group also decreased from baseline to week 4 and week 8 (both in particular, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Investigator's assessment and patient satisfaction in treatment group at week 8 were better than control group. Adverse events in two groups were similar.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>We think the cleanser with 5\u2010aminolevulinic acid and peptides is a useful and safe therapeutic agent for mild to moderate acne vulgaris.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13232","type":"journal-article","created":{"date-parts":[[2019,11,28]],"date-time":"2019-11-28T11:28:10Z","timestamp":1574940490000},"page":"1745-1750","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Randomized controlled double\u2010blind study of a cleanser composed of 5\u2010aminolevulinic acid and peptides on mild and moderate acne vulgaris"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4222-1835","authenticated-orcid":false,"given":"Hyun Ji","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Dermatology School of Medicine Kyungpook National University 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