{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T16:37:11Z","timestamp":1790354231643,"version":"4.1.0"},"reference-count":16,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Periorbital hyperpigmentation (POH) is a very common, yet unexplored aesthetic condition. Topical therapy is mainstay of treatment which includes chemical peels and other depigmenting agents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To compare clinical efficacy, safety, and tolerability of 20% glycolic acid peels, 15% lactic acid peels, and 12% ferulic acid peels in the treatment of constitutional type of periorbital hyperpigmentation in Indian patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ninety patients of constitutional POH were enrolled for 12 weeks. They were divided into three groups of 30 each. In 1st group 20% glycolic acid peeling, in 2nd group 15% lactic acid peeling and in 3rd group 12% ferulic acid peeling sessions were performed at 3 weekly intervals. Clinical improvement was assessed objectively using POH grading, physician's and patient's global assessment, and patient's global tolerance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant improvement in periorbital hyperpigmentation was noted in all the three groups. Physician and patient's global assessment was excellent with glycolic acid peel followed by ferulic acid peel and lactic acid peel. The incidence of side effects in the form of erythema and itching was maximum with glycolic acid followed by lactic acid and least with ferulic acid, which did not necessitate cessation of therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Glycolic acid produced the best results among the three peels; however, ferulic acid peel emerged as a safe and effective modality for the treatment of POH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13292","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T13:49:23Z","timestamp":1579182563000},"page":"2342-2348","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Ferulic acid 12% peel: An innovative peel for constitutional type of periorbital melanosis\u2014Comparing clinical efficacy and safety with 20% glycolic peel and 15% lactic peel"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9093-6731","authenticated-orcid":false,"given":"Surabhi","family":"Dayal","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Pt B. D. Sharma, University of Health Sciences Rohtak Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhavya","family":"Sangal","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Pt B. D. Sharma, University of Health Sciences Rohtak Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Priyadarshini","family":"Sahu","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Leprology Pt B. D. Sharma, University of Health Sciences Rohtak Haryana India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,1,16]]},"reference":[{"key":"e_1_2_7_2_1","first-page":"49","article-title":"Periorbital hyperpigmentation: a comprehensive review","volume":"9","author":"Sarkar R","year":"2016","journal-title":"J Clin Aesthet Dermatol"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1524-4725.2011.02065.x"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.127675"},{"key":"e_1_2_7_5_1","first-page":"177","volume-title":"Textbook of Dermatosurgery and Cosmetology","author":"Savant SS","year":"2005"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12255"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12044"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.185707"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.0893-5785.2000.130830.x"},{"key":"e_1_2_7_10_1","first-page":"341","volume-title":"Dermatology for Skin of Color","author":"Gathers RC","year":"2009"},{"key":"e_1_2_7_11_1","first-page":"5","article-title":"Standard guidance of care for chemical peels","volume":"74","author":"Khunger N","year":"2008","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/Pigmentinternational.Pigmentinternational_25_17"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0094-1298(20)32519-0"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.66602"},{"key":"e_1_2_7_15_1","first-page":"749","volume-title":"Textbook of Cutaneous & Aesthetic Surgery","author":"Talwar A","year":"2017"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/0891-5849(92)90184-I"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1080\/07388550490491467"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.13292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13292","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13292","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13292","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,5]],"date-time":"2023-09-05T14:56:34Z","timestamp":1693925794000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13292"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1,16]]},"references-count":16,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2020,9]]}},"alternative-id":["10.1111\/jocd.13292"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13292","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,1,16]]},"assertion":[{"value":"2019-11-25","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2019-12-19","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-01-16","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}