{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,4]],"date-time":"2025-06-04T21:13:46Z","timestamp":1749071626957,"version":"3.40.5"},"reference-count":25,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T00:00:00Z","timestamp":1579132800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Research Fund of the Van Yuzuncu Yil University","award":["2015-TF-U247"],"award-info":[{"award-number":["2015-TF-U247"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Pemphigus vulgaris (PV) is a chronic progressive autoimmune bullous disease caused by the interaction of pathogenic factors, genetic, and environmental factors. HLA alleles, which are considered as protective factors against disease or predisposing factors, may be different in various populations and ethnic groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of this study is to examine the HLA\u2010A, HLA\u2010DR, and HLA\u2010DQ alleles in patients that are diagnosed with PV in and around eastern of Turkey and to determine the alleles that create predisposition to disease or protect against the disease.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Thirty patients diagnosed as PV with clinical, histopathological, and immunofluorescence findings and 30 healthy subjects were included in this study. The HLA\u2010A, HLA\u2010DR, and HLA\u2010DQ typology in the DNA samples that were obtained from the blood samples of the groups was performed by using the PCR\u2010SSP low\u2010resolution gene panels.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The HLA\u2010A*03 allele was found to be significantly higher in patient group than the control group (<jats:italic>P<\/jats:italic>\u2010value: .020). HLA\u2010DRB1*04 and HLA\u2010DRB1*14 alleles in PV patients were found to be significantly higher than the control group (<jats:italic>P<\/jats:italic>\u2010value\u00a0=\u00a0.000).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>It was concluded that the HLA\u2010DRB1*03, HLADQB1*02, and HLA\u2010DQB1*06 alleles in and around eastern of Turkey showed protective effects against pemphigus vulgaris. It was also concluded that the HLA\u2010A*03, HLA\u2010DRB1*04, HLA\u2010DRB1*14, HLA\u2010DRB4, HLA\u2010DQB1*03, and HLA\u2010DQB1*05 alleles could cause predisposition to the disease.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13298","type":"journal-article","created":{"date-parts":[[2020,1,16]],"date-time":"2020-01-16T16:05:51Z","timestamp":1579190751000},"page":"2432-2437","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Assessment of HLA\u2010A, HLA\u2010DR, and HLA\u2010DQ alleles in patients with pemphigus vulgaris from eastern of Turkey"],"prefix":"10.1111","volume":"19","author":[{"given":"Gokturk","family":"Dere","sequence":"first","affiliation":[{"name":"Department of Dermatology Ordu State Hospital Ordu Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ibrah\u0131m Halil","family":"Yavuz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Van Yuzuncu Yil University Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Goknur","family":"Ozayd\u0131n Yavuz","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Van Yuzuncu Yil University Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yasemin","family":"Bayram","sequence":"additional","affiliation":[{"name":"Department of Medical Microbiology Faculty of Medicine Van Yuzuncu Yil University Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Serap","family":"Gunes Bilgili","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Van Yuzuncu Yil University Van Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4499-3724","authenticated-orcid":false,"given":"Murat","family":"Ozturk","sequence":"additional","affiliation":[{"name":"Department of Dermatology Van Training and 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