{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T20:01:52Z","timestamp":1783022512580,"version":"3.54.6"},"reference-count":20,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T00:00:00Z","timestamp":1579478400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81502739"],"award-info":[{"award-number":["81502739"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Nature Science Foundation of China","doi-asserted-by":"crossref","award":["81371750"],"award-info":[{"award-number":["81371750"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Jiang Su National Nature Science Foundation","award":["BK20150068"],"award-info":[{"award-number":["BK20150068"]}]},{"name":"Medical science and technology innovation project of Chinese academy of medical sciences","award":["CIFMS-2017-I2M-1-017"],"award-info":[{"award-number":["CIFMS-2017-I2M-1-017"]}]},{"name":"Medical science and technology innovation project of Chinese academy of medical sciences","award":["CIFMS-2018-I2M- AI-018"],"award-info":[{"award-number":["CIFMS-2018-I2M- AI-018"]}]},{"name":"Key R&D Plans of Jiangsu Province","award":["BE2017808"],"award-info":[{"award-number":["BE2017808"]}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Purpose<\/jats:title><jats:p>Radiofrequency equipment, including invasive fractional microneedle radiofrequency (FMR) and noninvasive fractional radiofrequency (FR), has facilitated progress in the field of active acne treatment, but clinical data are limited. This study aimed to compare the efficacy and safety of FMR and FR in the treatment of moderate\u2010to\u2010severe acne vulgaris.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Ten patients with moderate\u2010to\u2010severe acne were enrolled in a 24\u2010week, prospective, single\u2010blind, randomized, comparative clinical trial with a split\u2010face design. Fractional microneedle radiofrequency treatment was provided on one side of the face and FR on the opposite side. Three consecutive treatments were performed at 4\u2010week interval. Objective assessment of efficacy was performed using the Acne Severity Index (ASI), and acne inflammatory lesions and noninflammatory lesions were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After the first treatment, ASI and both inflammatory and noninflammatory lesions of the FMR\u2010treated side were improved to a greater degree than the FR\u2010treated side. Patients' subjective satisfaction was also better regarding the FMR\u2010treated side. After subsequent treatments, efficacy improves for both groups, and no significant differences in the above efficacy parameters between the two groups were observed. Pain scores were significantly higher for the FR\u2010treated side than the FMR\u2010treated side.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fractional microneedle radiofrequency is faster and more effective than FR for the treatment of moderate and severe acne after only one treatment. However, after several treatment sessions, both FMR and FR proved to be safe and effective for long\u2010term treatment of moderate\u2010to\u2010severe acne. Therefore, invasive radiofrequency, such as FMR, or noninvasive radiofrequency, such as FR, can successfully treat active acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13299","type":"journal-article","created":{"date-parts":[[2020,1,20]],"date-time":"2020-01-20T12:21:05Z","timestamp":1579522865000},"page":"2566-2571","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["A split\u2010face comparison of a fractional microneedle radiofrequency device and fractional radiofrequency therapy for moderate\u2010to\u2010severe acne vulgaris"],"prefix":"10.1111","volume":"19","author":[{"given":"Rong","family":"Zeng","sequence":"first","affiliation":[{"name":"Cosmetic lasers Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuzhen","family":"Liu","sequence":"additional","affiliation":[{"name":"Cosmetic lasers Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenwen","family":"Zhao","sequence":"additional","affiliation":[{"name":"Cosmetic lasers Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yin","family":"Yang","sequence":"additional","affiliation":[{"name":"Cosmetic lasers Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiuju","family":"Wu","sequence":"additional","affiliation":[{"name":"Cosmetic lasers Institute of Dermatology Chinese Academy of Medical Sciences and Peking Union Medical College Nanjing 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