{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T08:09:21Z","timestamp":1768637361844,"version":"3.49.0"},"reference-count":55,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T00:00:00Z","timestamp":1582675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is a chronic disfiguring inflammatory disease of adolescents and adults affecting up to 90% of the population around the world. The sequence of etiopathogenesis in acne is not completely understood but involves abnormalities in sebum production, follicular plugging, proliferation of propionibacterium acnes, and chronic inflammation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This review aims to summarize the features of the topical selective RAR agonists in treating acne vulgaris with a special emphasis on the 4th generation topical retinoid trifarotene.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Studies were identified by searching electronic databases (MEDLINE and PubMed) till August 2019 and reference lists of respective articles. Only articles published in English language were included.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Topical retinoids have been first line of treatment for more than 30\u00a0years now in treating mild to moderate acne vulgaris. Third generation retinoids like adapalene and tazarotene are selective RAR and \u03b3 agonists, having an additional anti\u2010inflammatory action along with their comedolytic effects and work well in combinations with topical antibiotics, due to the stability of chemical composition.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Trifarotene is a new 4th generation retinoid with selective action on RAR\u2010\u03b3 receptor alone, which is specific for skin, and it is safe for long\u2010term maintenance therapy with good efficacy and tolerability.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13340","type":"journal-article","created":{"date-parts":[[2020,2,26]],"date-time":"2020-02-26T09:25:20Z","timestamp":1582709120000},"page":"1278-1283","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Selective RAR agonists for acne vulgaris: A narrative review"],"prefix":"10.1111","volume":"19","author":[{"given":"Martin","family":"Kassir","sequence":"first","affiliation":[{"name":"Worldwide laser institute Dallas TX USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Priyanka","family":"Karagaiah","sequence":"additional","affiliation":[{"name":"Department of Dermatology Bangalore Medical College and Research Institute Bangalore India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7444-4956","authenticated-orcid":false,"given":"Sidharth","family":"Sonthalia","sequence":"additional","affiliation":[{"name":"Skinnocence: The Skin Clinic Department of Dermatology &amp; STD Kalyani\u2010Escorts Hospital Gurgaon India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andreas","family":"Katsambas","sequence":"additional","affiliation":[{"name":"University of Athens Athens Greece"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8223-2769","authenticated-orcid":false,"given":"Hassan","family":"Galadari","sequence":"additional","affiliation":[{"name":"College of Medicine and Health Sciences United Arab Emirates University Al Ain United Arab Emirates"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mrinal","family":"Gupta","sequence":"additional","affiliation":[{"name":"Treatwell Skin Centre Jammu India"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Torello","family":"Lotti","sequence":"additional","affiliation":[{"name":"University of Studies Guglielmo Marconi Rome Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5933-2913","authenticated-orcid":false,"given":"Uwe","family":"Wollina","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Allergology St\u00e4dtisches Klinikum Dresden Academic Teaching Hospital of the Technical University of Dresden Dresden Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman","family":"Abdelmaksoud","sequence":"additional","affiliation":[{"name":"Mansoura Dermatology, Venerology and Leprology Hospital Mansoura Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephan","family":"Grabbe","sequence":"additional","affiliation":[{"name":"Department of Dermatology University Medical Center of the Johannes Gutenberg University Mainz Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8646-1179","authenticated-orcid":false,"given":"Mohamad","family":"Goldust","sequence":"additional","affiliation":[{"name":"Department of Dermatology University of Rome G. 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