{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,5]],"date-time":"2025-07-05T01:13:43Z","timestamp":1751678023972,"version":"3.40.5"},"reference-count":2,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T00:00:00Z","timestamp":1584057600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Some moisturizing formulations can help restore and maintain the barrier function of the skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>This study was designed to assess the hydration potential of three lamellar moisturizers relative to a control (nonlamellar) moisturizer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Healthy adults aged 18 to 65\u00a0years with self\u2010reported sensitive skin, dry or very dry skin and Corneometry values of \u226440 a.u. on the lower legs, entered this randomized, evaluator\u2010blind study. Products A and B together with a control product (Control X) were applied to one leg, while Product C and Control Y were applied to the other leg; with an untreated control site in both cases. The primary efficacy variable was the change from baseline in Corneometer assessments at 24\u00a0hours (Products A and B) or 12\u00a0hours (Product C) postapplication.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At all timepoints (n\u00a0=\u00a030), Products A and B showed higher mean Corneometer readings compared to baseline and changes from baseline were statistically significant when compared to untreated sites. Higher mean readings relative to baseline were seen at sites treated with Control X (smaller magnitude than Product A and B) and with Product C. These changes were significant compared to the untreated site at 30\u00a0minutes and 2\u00a0hours (Control X), and at 30\u00a0minutes and 12\u00a0hours (Product C). Additionally, Control Y increased significantly at 12\u00a0hours.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A single application of a lamellar moisturizer significantly increased hydration of the stratum corneum for up to 24\u00a0hours (Products A and B) or 12\u00a0hours (Product C).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13361","type":"journal-article","created":{"date-parts":[[2020,3,13]],"date-time":"2020-03-13T10:35:01Z","timestamp":1584095701000},"page":"3091-3095","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Single application of lamellar moisturizers provides significantly increased hydration of the stratum corneum for up to 24 hours in a randomized trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7209-9586","authenticated-orcid":false,"given":"Stephanie J.","family":"Nisbet","sequence":"first","affiliation":[{"name":"Skin Health Medical Affairs GSK Consumer Healthcare Weybridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Dykes","sequence":"additional","affiliation":[{"name":"Cutest Systems Ltd Cardiff UK"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3616-0159","authenticated-orcid":false,"given":"Jane","family":"Snatchfold","sequence":"additional","affiliation":[{"name":"Skin Health Medical Affairs GSK Consumer Healthcare Weybridge UK"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,3,13]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2005.01326.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/archderm.1988.01670060015008"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.13361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13361","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13361","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13361","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T07:06:00Z","timestamp":1693724760000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13361"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3,13]]},"references-count":2,"journal-issue":{"issue":"11","published-print":{"date-parts":[[2020,11]]}},"alternative-id":["10.1111\/jocd.13361"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13361","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"type":"print","value":"1473-2130"},{"type":"electronic","value":"1473-2165"}],"subject":[],"published":{"date-parts":[[2020,3,13]]},"assertion":[{"value":"2019-07-30","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-02-18","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-03-13","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}