{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,2]],"date-time":"2026-02-02T18:53:34Z","timestamp":1770058414168,"version":"3.49.0"},"reference-count":34,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is one of the common pigmentary disorders affecting the ocular structures.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>To determine the retinal nerve fiber layer (RNFL), retinal pigment epithelium (RPE), and choroidal thickness (CT) in vitiligo patients and to evaluate the relationship between choroidal thickness and vitiligo subtypes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The right eyes of 106 participants (51 vitiligo, 55 nonvitiligo) were included in the study. All of the participants underwent detailed eye examinations and spectral\u2010domain optical coherence tomography (SD\u2010OCT) examinations. CT was measured manually with enhanced depth imaging optical coherence tomography (Edi\u2010OCT) (subfoveal [SubF], nasal n500\u00a0\u00b5m [N1], n1500\u00a0\u00b5m [N2]), and temporal (t500\u00a0\u00b5m [T1], t1500\u00a0\u00b5m [T2]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In vitiligo patients, CT values were significantly lower in the SubF, N1, N2, T1, and T2 areas compared to the control group (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.011, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.005, <jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a0.001, respectively). Periorbital involvement did not affect CT (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.355, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.746, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.443, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.633, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.558, respectively). However, in patients with periorbital region involvement, the CT was significantly reduced if the lesion had a universal character (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a0.001, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.011, <jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a0.001, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.002, respectively). It was observed that RPE thickness decreased in vitiligo, but this difference was not statistically significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.140). RNFL thickness was unaffected in all quadrants. A positive correlation (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.286, <jats:italic>r<\/jats:italic>\u00a0=\u00a0.280, respectively) was observed between the Vitiligo Area Severity Index (VASI) and age and disease duration. A negative correlation (<jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.360, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.316, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.315, <jats:italic>r<\/jats:italic>\u00a0=\u00a0\u2212.313, respectively) was found in the CT of the SubF, N1, N2, T1, and T2 areas.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Vitiligo patients should be closely monitored for possible posterior ocular segment disorders.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13367","type":"journal-article","created":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T16:27:11Z","timestamp":1591720031000},"page":"3032-3037","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Retinal nerve fiber layer, retinal pigment epithelium, and choroidal thickness in vitiligo 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