{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T11:46:12Z","timestamp":1775216772220,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T00:00:00Z","timestamp":1584662400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma is a difficult to treat pigmentation disorder. However, some successes have been attained by microneedling. The aim of the present study was to evaluate the efficacy of microneedling using meso\u2010depigmentation solution (mesoneedling) in comparison with standard microneedling, over a 4\u2010month treatment period.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>As a part of this pilot study, 20 patients received microneedling on one side and mesoneedling on another side of their face. Treatment was repeated on a monthly basis for 4\u00a0months. Treatment efficacy was defined through Dermacatch<jats:sup>\u00ae<\/jats:sup> colorimetry, modified Melasma Area and Severity (mMASI) score determination, Investigator's Global Assessment (IGA), and patient questionnaires, whereby all assessments were conducted at the baseline, as well after 2 and 4\u00a0months of treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Before treatments, mean difference between pigmented and normal skin calculated by Dermacatch<jats:sup>\u00ae<\/jats:sup> was 43.7\u00a0\u00b1\u00a020.12 and 44.6\u00a0\u00b1\u00a020.72 in microneedling sides and mesoneedling sides, respectively. After two and four sessions, these values declined to 34.5\u00a0\u00b1\u00a016.26 and 28.05\u00a0\u00b1\u00a013.79 on the side subjected to microneedling, while 29.75\u00a0\u00b1\u00a015.07 and 20.45\u00a0\u00b1\u00a010.58 were measured on the mesoneedling side. Statistically significant differences have been observed between microneedling and mesoneedling treatments at both time points (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.0001, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.0001). The mMASI scores obtained upon treatment completion were significantly lower on both the microneedling and the mesoneedling side. The IGA and patients' self\u2010assessment scores further confirmed that both treatments were effective in treating melasma, without producing any notable side\u2010effects or complications.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In sum, both microneedling and mesoneedling are effective in decreasing melanin content in the epidermal melasma lesions.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13369","type":"journal-article","created":{"date-parts":[[2020,3,20]],"date-time":"2020-03-20T18:41:17Z","timestamp":1584729677000},"page":"1093-1098","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Study of efficacy of microneedling and mesoneedling in the treatment of epidermal melasma: A pilot trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0575-4381","authenticated-orcid":false,"given":"Susan","family":"Farshi","sequence":"first","affiliation":[{"name":"Tehran University of Medical Sciences Tehran Iran"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Parvin","family":"Mansouri","sequence":"additional","affiliation":[{"name":"Skin and Stem Cell Research Center Tehran University of Medical Sciences Tehran 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