{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:36:04Z","timestamp":1788428164246,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"11","license":[{"start":{"date-parts":[[2020,5,13]],"date-time":"2020-05-13T00:00:00Z","timestamp":1589328000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,11]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>There are various treatment modalities for melasma, but none of them are effective on dermal component of melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this study, we decided to evaluate the efficacy of microneedling plus tranexamic acid in comparison with 4% hydroquinone in the treatment of melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a single\u2010blind randomized clinical trial on 70 participants with 14% dropout, and therefore, 60 patients with melasma completed the study. Patients were randomized based on simple randomization in 2 groups of A (microneedling plus topical 4% tranexamic acid, monthly) and B (topical 4% hydroquinone, nightly). Evaluation of mean MASI score, patient and physician assessments was performed at 4th, 8th and12th weeks of the treatment. Statistical analysis was performed by paired t test, chi\u2010square test and Fisher's exact test, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sixty women (30 patients in each group) were completed the study. Mean MASI score in group A was significantly lower at the end of the treatment (6.84\u00a0\u00b1\u00a04.31) than at the baseline (12.89\u00a0\u00b1\u00a05.16) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). Mean MASI score in group B was significantly lower at the end of the treatment (7.16\u00a0\u00b1\u00a04.38) than at the baseline (13.56\u00a0\u00b1\u00a04.88) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). There was no statistical difference between 2 groups regarding MASI score, physician and patient assessments during the treatment. Percentage of patient satisfaction was significantly higher than physician satisfaction in both treatment groups (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In our study, the combination of microneedling with tranexamic acid did not differ from 4% hydroquinone in the treatment of melasma.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13392","type":"journal-article","created":{"date-parts":[[2020,5,14]],"date-time":"2020-05-14T01:33:17Z","timestamp":1589419997000},"page":"2906-2911","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":34,"title":["Efficacy of microneedling plus topical 4% tranexamic acid solution vs 4% hydroquinone in the treatment of melasma: A single\u2010blind randomized clinical trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Simin","family":"Shamsi Meymandi","sequence":"first","affiliation":[{"name":"Pathology and Stem 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