{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,16]],"date-time":"2026-04-16T02:02:32Z","timestamp":1776304952225,"version":"3.50.1"},"reference-count":18,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,4,12]],"date-time":"2020-04-12T00:00:00Z","timestamp":1586649600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Inappropriate feminine hygiene practices are related to vulvar unpleasant symptoms (such as skin changes, lesions, burning, pruritus, fissures, and dyspareunia).<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We assessed the daily use effects of intimate cleansers on vulvar skin by comparing two specific products for intimate care: Saugella Hydraserum (SIS), based on natural extracts, and a standard product based on lactic acid, such as Lactacyd Feminine Hygiene (LTC). Forty healthy women were enrolled in this double\u2010blind controlled study.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>After randomization, the cleansers were used twice daily for 30\u00a0days. The hydration level was determined using the Corneometer<jats:sup>\u00ae<\/jats:sup> CM 825, the pH using the Skin\u2010pH\u2010Meter PH 905<jats:sup>\u00ae<\/jats:sup> and the sebum level using the Sebumeter SM815<jats:sup>\u00ae<\/jats:sup>. Measurements were performed at baseline and on day 30 on the labia majora and labia minora.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Both cleansers showed a reduction in the hydration level, but this was much less evident in the SIS group (\u22126.3% SIS vs \u221223,7% LTC). The pH values of the SIS group were lower than those of the LTC group, especially on the labia minora (5.27\u00a0\u00b1\u00a00.08 and 5.6\u00a0\u00b1\u00a00.1, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.025). The sebum increased in both groups, but in the LTC group, it was higher on the labia majora (+96.2% vs +46.8%, respectively, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.003), while on the labia minora, it was higher in the SIS group (+24.7% vs +17.1%, respectively <jats:italic>P<\/jats:italic>\u00a0=\u00a0NS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Both cleansers tested showed high performance for safety and tolerability on vulvar skin, but SIS showed better efficacy than LTC on some parameters.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13402","type":"journal-article","created":{"date-parts":[[2020,4,13]],"date-time":"2020-04-13T05:29:44Z","timestamp":1586755784000},"page":"2721-2726","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Characterization of female intimate hygiene practices and vulvar health: A randomized double\u2010blind controlled trial"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9966-6448","authenticated-orcid":false,"given":"Filippo","family":"Murina","sequence":"first","affiliation":[{"name":"Lower Genital Tract Disease Unit V. Buzzi Hospital\u2013University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Camilla","family":"Caimi","sequence":"additional","affiliation":[{"name":"Lower Genital Tract Disease Unit V. Buzzi Hospital\u2013University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raffaele","family":"Felice","sequence":"additional","affiliation":[{"name":"Lower Genital Tract Disease Unit V. Buzzi Hospital\u2013University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Di Francesco","sequence":"additional","affiliation":[{"name":"Lower Genital Tract Disease Unit V. Buzzi Hospital\u2013University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Irene","family":"Cetin","sequence":"additional","affiliation":[{"name":"Lower Genital Tract Disease Unit V. Buzzi Hospital\u2013University of Milan Milan Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,4,12]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/jdv.14096"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/ced.12330"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1159\/000082570"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9378(00)61320-0"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.1992.tb08403.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2305-0500(13)60114-1"},{"issue":"4","key":"e_1_2_7_8_1","first-page":"288","article-title":"Prevalence of bacterial vaginosis and impact of genital hygiene practices in nonpregnant women in Zanjan, Iran","volume":"24","author":"Bahram A","year":"2009","journal-title":"Oman Med J"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.2011.00573.x"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/srt.12023"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/ics.12258"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0846.1997.tb00174.x"},{"key":"e_1_2_7_13_1","first-page":"59","article-title":"Getting intimate with polymers: personal lubricants","volume":"123","author":"Fevola MJ","year":"2008","journal-title":"Cosmet Toilet"},{"key":"e_1_2_7_14_1","first-page":"244","article-title":"Pharmacological, microbiological and clinical activity of feminine intimate cleansers based on plant extracts active principles (Saugella line)","volume":"4","author":"Leo VD","year":"2015","journal-title":"J Women\u2019s Health Care"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1396-0296.2004.04S1002.x"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01399.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0104-42302011000400015"},{"key":"e_1_2_7_18_1","unstructured":"Royal College of General Practitioners.The management of vulval skin disorders http:\/\/www.snhcic.org.uk\/assets\/cms_page_media\/211\/RCOG%20\u2010%20Vulval%20Skin%20.Disorders.pdf(2011 accessed December 2017)."},{"key":"e_1_2_7_19_1","first-page":"405","volume-title":"Skin Moisturization. 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