{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:34:48Z","timestamp":1747186488094,"version":"3.40.5"},"reference-count":17,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T00:00:00Z","timestamp":1587772800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Helicobacter pylori (<jats:italic>H\u00a0pylori<\/jats:italic>) may play a role in the pathogenesis of extra\u2010intestinal disorders including dermatological diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed to assess the levels of <jats:italic>H\u00a0pylori<\/jats:italic> antigen and antibody in patients with acne vulgaris (AV).<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study compared the levels of fecal <jats:italic>H\u00a0pylori<\/jats:italic> antigen and serum <jats:italic>H\u00a0pylori<\/jats:italic> antibody in 100 patients with AV and 100 age and sex\u2010matched healthy volunteers. Patients with AV were classified into mild, moderate, and severe according to the Global Acne Grading Scale. Levels of\u00a0fecal <jats:italic>H\u00a0pylori<\/jats:italic> antigen and serum <jats:italic>H\u00a0pylori<\/jats:italic> antibodies were assessed using commercially available enzyme\u2010linked immune\u2010sorbent assay.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The patients with severe AV had significantly higher levels of fecal <jats:italic>H\u00a0pylori<\/jats:italic> antigen as compared to the patients with mild AV, moderate AV, and healthy controls (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). The patients with severe AV had significantly higher serum <jats:italic>H\u00a0pylori<\/jats:italic> antibody as compared to the patients with mild AV, moderate AV, and healthy controls (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). The levels of fecal <jats:italic>H\u00a0pylori<\/jats:italic> antigen and serum <jats:italic>H\u00a0pylori<\/jats:italic> antibody in the patients with mild AV were not significantly different from those in the patients with moderate AV (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.49 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.05, respectively).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The patients with severe AV had higher levels of fecal <jats:italic>H\u00a0pylori<\/jats:italic> antigen and serum <jats:italic>H\u00a0pylori<\/jats:italic> antibody as compared to the patients with mild and moderate AV and with healthy controls. The indicators of <jats:italic>H\u00a0pylori<\/jats:italic> infection were positively correlated with the severity and duration of AV.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13409","type":"journal-article","created":{"date-parts":[[2020,4,25]],"date-time":"2020-04-25T07:28:01Z","timestamp":1587799681000},"page":"3291-3295","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["High levels of Helicobacter pylori antigens and antibodies in patients with severe acne vulgaris"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0503-3533","authenticated-orcid":false,"given":"Ramadan","family":"Saleh","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Sohag University Sohag Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ahmed","family":"Sedky 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