{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,3]],"date-time":"2026-04-03T12:37:12Z","timestamp":1775219832167,"version":"3.50.1"},"reference-count":28,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,4,19]],"date-time":"2020-04-19T00:00:00Z","timestamp":1587254400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Psoriasis is an inflammatory disease that is mostly immune\u2010derived. It causes proliferation of skin cells, forming plaques. Psoriasis etiology is unknown. It might be multifactorial.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This work aimed to study Smad7 expression in psoriasis vulgaris patients in comparison with normal skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Thirty patients with psoriasis vulgaris in comparison with 20 age\u2010 and sex\u2010matched seemingly healthy individuals were selected. We used psoriasis area and severity index (PASI) to evaluate psoriasis severity. Skin biopsies were prepared from skin lesions (30), perilesions (30) and control (20) groups for histopathological and immunostaining evaluation of Smad7.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Smad7 was progressively upregulated in proliferating keratinocytes from controls (58.18\u00a0\u00b1\u00a030.93) to perilesional (106\u00a0\u00b1\u00a038.93) and lesional (156.33\u00a0\u00b1\u00a062.01) skin (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). Also, dermal inflammatory cells showed upregulation of Smad7 expression from control skin (40\u00a0\u00b1\u00a028.28) to skin lesions (137.33\u00a0\u00b1\u00a073.86) (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.010). Smad7 expression showed a positive significant correlation with psoriasis severity (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.452; <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.012).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Smad7 may be involved in increased keratinocyte proliferation as well as skin inflammation in psoriasis vulgaris patients.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13425","type":"journal-article","created":{"date-parts":[[2020,4,20]],"date-time":"2020-04-20T05:18:55Z","timestamp":1587359935000},"page":"3395-3402","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Smad7 in psoriasis vulgaris patients: A clinical and immunohistochemical study"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3781-8872","authenticated-orcid":false,"given":"Aiat Shaban","family":"Hemida","sequence":"first","affiliation":[{"name":"Pathology Department Faculty of Medicine Menoufia University Shebin El Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mostafa Ahmed","family":"Hammam","sequence":"additional","affiliation":[{"name":"Dermatology Department Faculty of Medicine Menoufia University Shebin El Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arwa Tawfik Ahmed","family":"Salman","sequence":"additional","affiliation":[{"name":"Health Sector Shibin El Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-8261","authenticated-orcid":false,"given":"Wafaa Ahmed","family":"Shehata","sequence":"additional","affiliation":[{"name":"Dermatology Department Faculty of Medicine Menoufia University Shebin El Kom 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