{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T02:50:45Z","timestamp":1783047045704,"version":"3.54.6"},"reference-count":51,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,24]],"date-time":"2020-05-24T00:00:00Z","timestamp":1590278400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne scars are the most common sequelae of the severe inflammatory process of acne, and its managing is a challenge. Objective of this study was to assess safety and effectiveness of calcium hydroxylapatite monotherapy and its association with high\u2010intensity microfocused ultrasound for treating moderate\u2010to\u2010severe atrophic acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Women with moderate\u2010to\u2010severe atrophic scars of the face were enrolled on the study. Assessments were made by digital macrophotographs, Vectra H2, and Antera 3D.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>From October to December 2019, twenty women which fitted the inclusion criteria signed a consent form and received 3.0\u00a0mL of calcium hydroxylapatite and after 4\u00a0weeks, 400 lines of HIFU. No major side effects were reported during the study, and all patients completed the follow\u2010up after 6\u00a0months. At 1\u00a0month, patients treated with calcium hydroxylapatite (group 1) improved wrinkles and skin texture compared to placebo (group 2). At 3 and 6\u00a0months, all patients improved acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study showed that that both calcium hydroxylapatite and HIFU in monotherapy were safe and effective treatments for atrophic scar acne. Calcium hydroxylapatite was clinically effective when compared with placebo, though the combination of calcium hydroxylapatite and HIFU did not enhance the clinical efficacy compared to monotherapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13472","type":"journal-article","created":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T07:04:40Z","timestamp":1589007880000},"page":"53-61","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Prospective and randomized comparative study of calcium hydroxylapatite vs calcium hydroxylapatite plus HIFU in treatment of moderate\u2010to\u2010severe acne scars"],"prefix":"10.1111","volume":"20","author":[{"given":"Araco","family":"Antonino","sequence":"first","affiliation":[{"name":"Aesthetic Medicine Department Cosmetic Surgeon at Univeristy Tor Vergata of Roma Rome 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