{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T05:29:10Z","timestamp":1790659750190,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,10]],"date-time":"2020-06-10T00:00:00Z","timestamp":1591747200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Postacne erythema (PAE) is a common sequela of inflammatory acne vulgaris, treatment of which has been challenging due to limited options available and the variability of results for each modality. Recently, a 577\u2010nm high\u2010power optically pumped semiconductor laser (HOPSL) initially developed for vascular lesions has shown promising results for the treatment of PAE.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the efficacy and safety of 577\u2010nm HOPSL in the treatment of postacne erythema.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This was a split\u2010face, randomized controlled trial pilot study. Twenty\u2010one patients with PAE on both sides of their face were enrolled. Each subject's face sides were randomly assigned to either receive 577\u2010nm HOPSL treatment (QuadroStar PRO\u2122, Asclepion Laser Technologies) using the scanner handpiece, 1mm spot size, 80% coverage, 12\u201015\u00a0J\/cm<jats:sup>2<\/jats:sup>, 30\u00a0ms, 2 passes for 3 sessions at 1\u2010month intervals, or no treatment at all. Outcome measures such as overall improvement, the Erythema Index (EI), and Melanin Index (MI) from 3 different areas on both treatment and control sides were assessed at baseline, and 1\u2010month follow\u2010up after each treatment session. Side effects including pain, erythema, swelling, and crusting were also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Upon completion of the treatment period, the mean EI was significantly decreased in both treated and nontreated sides of the face (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001 and <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001, respectively). The laser\u2010treated sides already demonstrated significant reduction in the mean EI compared with nontreated sides at 1\u00a0month after the 2nd treatment (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.007). The mean MI of both sides, however, did not show any statistically significant differences from baseline, and likewise when comparing between sides. Patients reported more improvement on laser\u2010treated sides compared with nontreated sides. Reported side effects were limited to mild discomfort during treatment and transient facial erythema lasting approximately 30\u00a0minutes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Patients who received treatment with the 577\u2010nm HOPSL had better outcomes with minimal side effects at 1\u00a0month after 2 treatments as compared to those who did not receive any treatment. Therefore, the 577\u2010nm HOPSL may be considered as an effective adjuvant treatment for PAE and early erythematous atrophic scars.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13474","type":"journal-article","created":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T20:39:12Z","timestamp":1588970352000},"page":"1642-1647","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["The efficacy and safety of a 577\u2010nm high\u2010power optically pumped semiconductor laser in the treatment of postacne erythema"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3926-2193","authenticated-orcid":false,"given":"Rungsima","family":"Wanitphakdeedecha","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok 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