{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:53:58Z","timestamp":1773892438628,"version":"3.50.1"},"reference-count":26,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2020,6,9]],"date-time":"2020-06-09T00:00:00Z","timestamp":1591660800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,7]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Multiple treatment modalities have been developed to treat atrophic acne scars with varying degrees of success. Post\u2010inflammatory hyperpigmentation (PIH) after acne scar treatments remain a major concern in Asian patients. Fractional radiofrequency (FRF) has been used in many dermatological skin conditions including acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To determine the efficacy and safety of FRF nanoneedle system in the treatment of acne scars in Asians.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This is a prospective, evaluator\u2010blinded study with 25 subjects diagnosed with moderate to severe acne scarring. All subjects received 3 monthly treatments of the FRF nanoneedle system on both cheeks. Primary outcome was the clinical improvement of acne scars graded by 2 blinded dermatologists at baseline, 1\u2010, 3\u2010, and 6\u2010month follow\u2010ups. Objective scar volume analysis was done using ultraviolet A (UVA) light video camera. Subjects\u2019 self\u2010assessment, pain score, and adverse events were also recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010three out of 25 subjects completed the study and attended all follow\u2010up. Clinical improvement of acne scars was observed as early as 1\u2010month follow\u2010up. Objective evaluation of acne scar volume decreased significantly on all follow\u2010up compared to baseline (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.005). Majority of the subjects (48%) reported marked improvement in their acne scars. Adverse events such as pain, erythema, burning sensation, edema, scab formation, and PIH were mild and temporary.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>FRF nanoneedle system is a safe and effective treatment for acne scars in Asians. However, despite the significant changes in the scar volume, caution should be used to avoid excessive coagulation resulting in PIH.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13484","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T22:05:30Z","timestamp":1589666730000},"page":"1636-1641","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["The efficacy and safety of fractional radiofrequency nanoneedle system in the treatment of atrophic acne scars in Asians"],"prefix":"10.1111","volume":"19","author":[{"given":"Sunatra","family":"Nitayavardhana","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Siriraj Hospital Mahidol University Bangkok 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