{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T12:46:17Z","timestamp":1791895577103,"version":"4.3.4"},"reference-count":35,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,5,28]],"date-time":"2020-05-28T00:00:00Z","timestamp":1590624000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background\/Objectives<\/jats:title><jats:p>CD4<jats:sup>+<\/jats:sup>\u00a0T helper (Th) cells through its pro\u2010inflammatory cell type, interleukin\u201017 (IL\u201017)\u2010generating cells and its anti\u2010inflammatory category forkhead box P3\u2010positive (FOXP3<jats:sup>+<\/jats:sup>) regulatory T (Treg) cells, play a vital role in the immune balance in inflammatory disorders. Therefore, assessment of both IL\u201017 and FOXP3 in acne vulgaris (AV), a chronic inflammatory disease of the pilosebaceous unit, could be of value in understanding AV pathogenesis. This study aimed to investigate the immunohistochemical expression of IL\u201017A and FOXP3 in acne vulgaris lesions versus normal skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Forty\u2010five AV patients and 25 controls were included in this case\u2010control study. Biopsies from participants were analyzed for IL\u201017A and FOXP3 immunohistochemical profiles using IL\u201017A and FOXP3 polyclonal antibodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared to controls, AV patients exhibited a significant increase of IL\u201017A percent of expression in epidermis (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.001), in lymphocytes in papillary dermis (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.001), and in perifollicular lymphocytic inflammatory infiltrate in AV lesions. Also, there was a significant elevation in FOXP3 percent of expression in epidermis (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.049) and in lymphocytes in papillary dermis (<jats:italic>P<\/jats:italic>\u00a0\u2264\u00a0.027) in acne patients than control. A significant positive correlation between IL\u201017A expression in papillary lymphocytes and in epidermal keratinocyte was observed (<jats:italic>r<\/jats:italic>\u00a0=\u00a0.537, <jats:italic>P<\/jats:italic>\u00a0=\u00a0.001). In acne vulgaris patients, the associations between IL\u201017A and FOXP3 expressions could not reach level of significance.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>There was an up\u2010regulation of IL\u201017A and FOXP3 in acne vulgaris development, but with independent roles. Moreover, targeting of IL\u201017A and FOXP3 may open the door for development of new therapeutic agents in acne vulgaris treatment.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13485","type":"journal-article","created":{"date-parts":[[2020,5,16]],"date-time":"2020-05-16T06:35:26Z","timestamp":1589610926000},"page":"330-337","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Tissue expression of IL\u201017A and FOXP3 in acne vulgaris patients"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0333-5506","authenticated-orcid":false,"given":"Azza Gaber Antar","family":"Farag","sequence":"first","affiliation":[{"name":"Dermatology, Andrology and STDs Department Faculty of Medicine Menoufia University Shebin ElKom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alaa Hassan","family":"Maraee","sequence":"additional","affiliation":[{"name":"Dermatology, Andrology and STDs Department Faculty of Medicine Menoufia University Shebin ElKom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dalia","family":"Rifaat Al\u2010Sharaky","sequence":"additional","affiliation":[{"name":"Pathology Department Faculty of Medicine Menoufia University Shebin ElKom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mustafa Elsayed","family":"Elshaib","sequence":"additional","affiliation":[{"name":"Medical Student Faculty of Medicine Menoufia University Shebin ElKom Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marwa Samir Mohamed","family":"Kohla","sequence":"additional","affiliation":[{"name":"Dermatology Ministry of Health Damanhour Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-8261","authenticated-orcid":false,"given":"Wafaa Ahmed","family":"Shehata","sequence":"additional","affiliation":[{"name":"Dermatology, Andrology and STDs Department 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