{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T01:25:59Z","timestamp":1791509159676,"version":"4.3.4"},"reference-count":27,"publisher":"Wiley","issue":"1","license":[{"start":{"date-parts":[[2020,6,1]],"date-time":"2020-06-01T00:00:00Z","timestamp":1590969600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,1]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Excessive androgenesis in the skin promotes sebaceous hyperproduction which is the onset of acne vulgaris pathogenesis. Free fatty acids and lipid accumulation in the glandular infundibulum culminates in microbiota imbalance, triggering inflammatory response and follicular hyperkeratinization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of this work was to present an alternative cosmetic treatment for acne skin care, focusing on the prevention of sebaceous gland dysregulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Insulin\u2010stimulated human sebocytes were treated with noncytotoxic concentrations of a DTRW cosmetic formulation. After 6\u00a0days of incubation, cell lysates were collected for testosterone, 5\u03b1\u2010reductase, and dyhidrotestosterone (DHT) quantitation. In parallel, cells were stained with Oil Red O to measure sebum production.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Human sebocytes were incubated with insulin to mimic a seborrheic microenvironment with overproduction of intracellular lipids and fatty acids. Concomitant incubation of cell cultures with DRTW was able to promote a 52.97% reduction in intracellular lipid content. The anti\u2010androgenic properties of DRTW had been proved by the reductions of testosterone (\u219359.90%), 5\u03b1 reductase (\u219359.34%), and DHT (\u219355.98%) levels in sebocyte cultures also stimulated with insulin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The results indicate a promising action of DRTW cosmetic formulation in preventing the development of acne lesions by mechanisms involving the modulation of cutaneous androgenesis and consequently the control of sebum overproduction, considered one of the leading causes of acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13503","type":"journal-article","created":{"date-parts":[[2020,5,20]],"date-time":"2020-05-20T20:16:05Z","timestamp":1590005765000},"page":"360-365","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Modulation of skin androgenesis and sebum production by a dermocosmetic formulation"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8844-2887","authenticated-orcid":false,"given":"Elisete Isabel","family":"Crocco","sequence":"first","affiliation":[{"name":"Santa Casa Medical and Hospital School Dermatologic Clinic  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evellin Barbosa","family":"Bonif\u00e1cio","sequence":"additional","affiliation":[{"name":"FQM Farmoqu\u00edmica S\/A  Rio de Janeiro Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0111-7596","authenticated-orcid":false,"given":"Gustavo","family":"Facchini","sequence":"additional","affiliation":[{"name":"Kosmoscience Group  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gustavo Henrique","family":"da Silva","sequence":"additional","affiliation":[{"name":"Kosmoscience Group  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle Sabrina","family":"da Silva","sequence":"additional","affiliation":[{"name":"Kosmoscience Group  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana Lucia Tabarini Alves","family":"Pinheiro","sequence":"additional","affiliation":[{"name":"Kosmoscience Group  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paula Voltarelli Franco","family":"Avelar","sequence":"additional","affiliation":[{"name":"Santa Casa Medical and Hospital School Dermatologic Clinic Rua Doutor Am\u00e2ncio de Carvalho  S\u00e3o Paulo Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7001-801X","authenticated-orcid":false,"given":"Samara","family":"Eberlin","sequence":"additional","affiliation":[{"name":"Kosmoscience Group  Campinas Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,6]]},"reference":[{"key":"e_1_2_5_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2002.00613.x"},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2004.00255.x"},{"issue":"1","key":"e_1_2_5_4_1","first-page":"99","article-title":"Suppression of sebum production and accumulation by \u03b2\u2010cryptoxanthin due to the inhibition of the expression of diacylglycerol acyltransferase\u20101 and perilipin in hamster sebocytes","volume":"3","author":"Sato T","year":"2013","journal-title":"J Cosm Dermatol Sci Appl"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.1055\/s-2007-961814"},{"key":"e_1_2_5_6_1","doi-asserted-by":"publisher","DOI":"10.4161\/derm.3.1.13900"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1590\/S0365-05962008000500010"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1210\/jcem.85.8.6710"},{"key":"e_1_2_5_9_1","doi-asserted-by":"publisher","DOI":"10.14310\/horm.2002.11109"},{"issue":"5","key":"e_1_2_5_10_1","first-page":"412","article-title":"Cortexolone 17\u03b1\u2010propionate (Clascoterone) is a novel androgen receptor antagonist that inhibits production of lipids and inflammatory cytokines from sebocytes in vitro","volume":"18","author":"Rosette C","year":"2019","journal-title":"J Drugs Dermatol"},{"key":"e_1_2_5_11_1","doi-asserted-by":"publisher","DOI":"10.2165\/00003495-200363150-00005"},{"key":"e_1_2_5_12_1","doi-asserted-by":"publisher","DOI":"10.1177\/0300060519847367"},{"key":"e_1_2_5_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/0022-1759(83)90303-4"},{"key":"e_1_2_5_14_1","unstructured":"OECD (Organization for Economic Co\u2010operation and Development) 129 Guidance Document on Using Cytotoxicity Tests to Estimate Starting Doses for Acute Oral Systemic Toxicity Tests. 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