{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,17]],"date-time":"2026-01-17T22:37:57Z","timestamp":1768689477649,"version":"3.49.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,6,16]],"date-time":"2020-06-16T00:00:00Z","timestamp":1592265600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Blue light from electronic devices enriched with a peak at 456\u00a0nm affects circadian rhythm and antioxidant balance of skin, necessitating the study of photoprotection against the 456\u2010nm blue light.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aims to report that blue light (456\u00a0nm) can cause skin pigmentation and proposes a new clinical evaluation method for blue light (456\u00a0nm) protection based on the skin pigmentation level.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>We developed a clinical device (ABC device<jats:sup>TM<\/jats:sup>) that emits\u00a0blue light (peak\u00a0=\u00a0456\u00a0nm). Based on the minimal persistent pigment darkening dose (MPPD) determined from visual evaluation and melanin index measurements, we proposed the \u201cprotection grade of blue light (PB)\u201d guideline to assess the protective ability of skin against blue light.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Human skin irradiated with blue light (456\u00a0nm) showed a light dose\u2010dependent degree of pigmentation. The MPPD on unprotected and protected skin was 135\u00a0J\/cm<jats:sup>2<\/jats:sup> or 180\u00a0J\/cm<jats:sup>2<\/jats:sup> and 135\u2010225\u00a0J\/cm<jats:sup>2<\/jats:sup>, respectively. The ABC device<jats:sup>\u2122<\/jats:sup> and the proposed clinical method were used to test the four blue light blocking assessments of TiO<jats:sub>2<\/jats:sub>. Consequently, the inorganic filter with TiO<jats:sub>2<\/jats:sub> effectively blocked the blue light (456\u00a0nm). The AP product demonstrated the ability to block blue light by 1.15 times (PB\u00a0=\u00a01.15), which significantly lowered the melanin index of the skin after irradiation as compared to that of the unprotected skin (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We propose an objective clinical evaluation method for blue light protection. This study elucidates the properties of blue light blockers for customers suffering from blue light pollution.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13508","type":"journal-article","created":{"date-parts":[[2020,5,27]],"date-time":"2020-05-27T20:24:00Z","timestamp":1590611040000},"page":"2438-2443","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Clinical evaluation method for blue light (456\u00a0nm) protection of skin"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1936-6761","authenticated-orcid":false,"given":"Hong Li","family":"Jo","sequence":"first","affiliation":[{"name":"AMOREPACIFIC R&amp;D Center Yongin\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuchul","family":"Jung","sequence":"additional","affiliation":[{"name":"AMOREPACIFIC R&amp;D Center Yongin\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung\u2010Fhy","family":"Suh","sequence":"additional","affiliation":[{"name":"AMOREPACIFIC R&amp;D Center Yongin\u2010si Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunbyul","family":"Cho","sequence":"additional","affiliation":[{"name":"Institute d\u2019Expertise Clinique Korea Gyeonggi\u2010do Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyungtae","family":"Kim","sequence":"additional","affiliation":[{"name":"Live Cell Instrument Seoul Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eunjoo","family":"Kim","sequence":"additional","affiliation":[{"name":"AMOREPACIFIC R&amp;D Center Yongin\u2010si 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