{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:41:30Z","timestamp":1790757690035,"version":"4.1.0"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T00:00:00Z","timestamp":1593475200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,8]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Needle\u2010free jet injection implements kinetic energy of liquid jet for transcutaneous delivery of drugs into soft tissues. Combination therapy of intralesional 5\u2010fluorouracil and triamcinolone offers efficacious treatment for keloids with a reduced adverse effect of the drug monotherapy. This study evaluates safety and efficacy of the drug combination administered to keloid scars via intralesional jet injections.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A retrospective analysis of the keloid treatments was performed. Efficacy was assessed by reviewing pre\u2010 and post\u2010treatment scores of the Vancouver Scar Scale (VSS) and Patient and Observer Scar Assessment Scale (POSAS) and by comparing baseline and photographs taken 3\u00a0months after the treatments. Safety and tolerability were collected and analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one subjects (M\/F\u00a0=\u00a011\/10) with 39 keloids received the treatments. Treatments were well\u2010tolerated by all patients at mean injection pain of 2.0\u00a0\u00b1\u00a01.0 per Numeric Pain Rating Scale (NPRS). Self\u2010resolved lesion ulceration was observed in 4 patients. Post\u2010treatment evaluation demonstrated a 53% decrease in total VSS score (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05) and in all sub\u2010categories. Mean patient score of POSAS decreased in the color, stiffness, thickness, and irregularity components. Pain and pruritus lessened by 69% and 79% (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a00.05 in both), respectively, among the patients with complaints prior to the treatment. Independent reviewers reported an average 51%\u201075% reduction in keloids.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Improved appearance of keloids and symptomatic relief was achieved by intralesional administration of combined 5\u2010fluorouracil and corticosteroid through the high\u2010pressure jet injections. The synergy between the drug combination and the jet physical impact provided clinical effect.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13522","type":"journal-article","created":{"date-parts":[[2020,6,30]],"date-time":"2020-06-30T12:48:08Z","timestamp":1593521288000},"page":"1966-1972","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":12,"title":["Potentials for implementing pressure\u2010controlled jet injection in management of keloids with intralesional 5FU and corticosteroids"],"prefix":"10.1111","volume":"19","author":[{"given":"Alex","family":"Levenberg","sequence":"first","affiliation":[{"name":"Department of Plastic Surgery Tel\u2010Aviv Sourasky Medical Center Tel Aviv Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8726-7370","authenticated-orcid":false,"given":"Yuri","family":"Vinshtok","sequence":"additional","affiliation":[{"name":"PerfAction Technologies Rehovot Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1391-5843","authenticated-orcid":false,"given":"Ofir","family":"Artzi","sequence":"additional","affiliation":[{"name":"Center for Aesthetic Dermatology Department of Dermatology Tel Aviv Sourasky Medical Center Tel Aviv 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