{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,29]],"date-time":"2026-01-29T13:16:28Z","timestamp":1769692588570,"version":"3.49.0"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T00:00:00Z","timestamp":1593043200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Skin\u2010lightening products are used worldwide to treat persistent pigmentation disorders that impact our quality of life and self\u2010confidence. However, consumers of cosmetic and over\u2010the\u2010counter skin lighteners struggle to find products that perform to their expectations. New, safe, and effective bioactives are needed to fill this gap.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To investigate the safety and skin\u2010lightening performance of a new topical tranexamic acid derivative, that is, cetyl tranexamate mesylate.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>The test material was a facial serum containing 2.0% (w\/w) of the new bioactive. Safety was evaluated by a modified Human Repeat Insult Patch Test with 54 subjects of either sex. Performance was objectively assessed based on the improvement of melanin and erythema indexes through time, and also subjectively by photographs and self\u2010perception questionnaires. Thirty\u2010five female subjects applied the serum twice a day for 8\u00a0weeks.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>No questionable adverse reactions were observed. Melanin and erythema indexes improved significantly and continuously from the baseline to the end of the study (\u221216.9% and \u221234.3%, respectively). Photographs further support instrumental data. On average, after 2\u00a0weeks, the subjects already noticed an improvement in skin tone (79.3%), a reduction in dark spots (78.6%), and an improvement in facial redness (77.1%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>A topical serum containing cetyl tranexamate mesylate was well\u2010tolerated and successfully improved the overall facial skin tone, as well as the appearance of dark spots and redness.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13545","type":"journal-article","created":{"date-parts":[[2020,6,26]],"date-time":"2020-06-26T05:35:06Z","timestamp":1593149706000},"page":"561-565","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["New topical tranexamic acid derivative for the improvement of hyperpigmentation and inflammation in the sun\u2010damaged skin"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6176-1135","authenticated-orcid":false,"given":"Ivan D.","family":"da Silva Souza","sequence":"first","affiliation":[{"name":"Actera Ingredients Inc. Newtown PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lorraine","family":"Lampe","sequence":"additional","affiliation":[{"name":"Actera Ingredients Inc. Newtown PA USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Winn","sequence":"additional","affiliation":[{"name":"Actera Ingredients Inc. 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