{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,29]],"date-time":"2025-12-29T18:44:37Z","timestamp":1767033877913,"version":"3.40.5"},"reference-count":19,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,12,18]],"date-time":"2020-12-18T00:00:00Z","timestamp":1608249600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81560507"],"award-info":[{"award-number":["81560507"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study is to evaluate the clinical efficacy and safety of a \u201cdouble\u2010layer\u201d mode of super pulse fractional CO<jats:sub>2<\/jats:sub> laser and a combined treatment of pinprick therapy with fractional CO<jats:bold><jats:sub>2<\/jats:sub><\/jats:bold> laser for the treatment of atrophic acne scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A split\u2010face and self\u2010contrast method was applied. A total of 20 patients with atrophic acne scars randomly received the above mentioned therapy on the left or right side of the cheek for 3 times with an interval of 3\u00a0months. ECCA scores, IVA scores, patients\u2019 satisfaction, VAS scores, and adverse reactions were evaluated.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Atrophic acne scars on both sides of the cheek were improved obviously. The ECCA scores showed a significant decrease, while IVA scores significantly increased. Compared with the super pulse fractional CO<jats:sub>2<\/jats:sub> laser group, the decrease of ECCA scores, the increase of IVA scores, and the patients\u2019 satisfaction were significantly higher and improvement on V\u2010shaped and U\u2010shaped acne scars was significantly better in the combined treatment group. No patients had severe adverse reactions such as blister, infection, or hypertrophic scars.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Super pulse fractional CO<jats:sub>2<\/jats:sub> laser and pinprick treatment combined with fractional CO<jats:sub>2<\/jats:sub> laser are both safe and effective therapy for the treatment of atrophic acne scars.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13568","type":"journal-article","created":{"date-parts":[[2020,6,25]],"date-time":"2020-06-25T21:56:20Z","timestamp":1593122180000},"page":"481-490","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Self\u2010contrast study of pinprick therapy combined with super pulse fractional CO<sub>2<\/sub> laser for the treatment of atrophic acne scars"],"prefix":"10.1111","volume":"20","author":[{"given":"Zhi","family":"Yang","sequence":"first","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song","family":"Jiang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yiqiong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Kunming Medical University  Kunming China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaxin","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Dermatology The First Affiliated Hospital of Kunming Medical University  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