{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T09:33:02Z","timestamp":1788427982609,"version":"build-2803163510"},"reference-count":27,"publisher":"Wiley","issue":"2","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"name":"Imperial Bioscience Ltd"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,2]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hyperpigmentation is a complex physiological process associated with alterations of skin color due to melanin overproduction and distribution. Both intrinsic and extrinsic factors influence discoloration with the involvement of multiple pathways in cooperative manners. Restoring natural skin color requires a multi\u2010targeted approach. Latest advances in anti\u2010melanogenic compounds and microneedle delivery system have presented opportunities for tackling hyperpigmentationsuccessfully.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This work was aimed at assessing the dermal tolerability and efficacy of hyaluronic acid\u2010based microneedle patches loaded with anti\u2010melanogenic actives for improvements of skin discoloration.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>The test products consist of hyaluronic acid with niacinamide, ascorbic acid 2\u2010glucoside, tranexamic acid, resveratrol, 4\u2010n\u2010butyl\u2010resorcinol, and <jats:italic>Halidrys siliquosa<\/jats:italic> extract. In a monocentric 12\u00a0weeks clinical trial, the HA\u2010MNs patches were applied to the affected areas of the faces on subjects with hyperpigmented skin. The color properties of the skin were analyzed spectrophotometrically.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The products were tolerated remarkably; none of the subjects informed any primary or cumulative skin responses. Evaluation of color related measurable skin properties provided insight into the general effectiveness: The individual topology measurements showed 51.4% noticeable improvements in hyperpigmented zones, which were also in good agreement with the personal impressions of the subjects determined by questionnaires before and after the treatments.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The concentrated blends of actives in microneedle patches act in a multi\u2010targeted manner, and they could be worked in a complementary fashion for the improvement of skin color and appearance. The study has established the overall convenience of the HA\u2010MNs with the formulation of anti\u2010melogenic compounds against skin discoloration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13571","type":"journal-article","created":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T18:49:50Z","timestamp":1595357390000},"page":"605-614","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Clinical efficacy of dissolvable microneedles armed with anti\u2010melanogenic compounds to counter hyperpigmentation"],"prefix":"10.1111","volume":"20","author":[{"given":"Muhammet","family":"Avcil","sequence":"first","affiliation":[{"name":"Imperial Bioscience Ltd. Brighton UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gokhan","family":"Akman","sequence":"additional","affiliation":[{"name":"Imperial Bioscience Ltd. 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