{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T09:22:31Z","timestamp":1780478551160,"version":"3.54.1"},"reference-count":27,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne vulgaris is a common skin disease in adolescents known to be associated with oxidative stress. However, the number of studies in which oxidative stress and antioxidants are evaluated together is limited.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>In this study, we aimed to investigate L\u2010arginine\/nitric oxide (NO) pathway metabolites, ischemia\u2010modified albumin (IMA), and vitamin A and E levels in patients with acne and its association with disease severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Ninety patients with acne and 30 healthy adults were included in the study. The serum levels ofL\u2010arjinin, L\u2010arginine metabolites, IMA, and vitamins A and E measured in the patient and control groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Asymmetric dimethylarginine (ADMA), LN<jats:sup>G<\/jats:sup>\u2010monomethyl\u2010L\u2010arginine (L\u2010NMMA) and symmetric dimethylarginine (SDMA), and IMA levels were significantly higher in the patients with acne than in the control group (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a0.05). The L\u2010arginine\/ADMA ratio and citrulline and vitamin A levels were significantly lower in patients with acne than those of the controls (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a0.05). ADMA and IMA plasma levels were increased in parallel with the disease severity (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a0.05). L\u2010arginine\/ADMA ratio, L\u2010arginine, citrulline, and vitamin A plasma levels decreased as the disease became severe (<jats:italic>P<\/jats:italic>\u00a0\u02c2\u00a0.05). Although L\u2010arginine and vitamin E levels were lower in the patient group compared to the control group, the difference was not statistically significant (<jats:italic>P<\/jats:italic>\u00a0\u02c3\u00a0.05).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>These results suggest that IMA and L\u2010arginine\u2010NO pathway associated with ischemia and oxidative stress may play an important role in the pathogenesis and progression of acne vulgaris.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13590","type":"journal-article","created":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T08:27:17Z","timestamp":1593937637000},"page":"3408-3413","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Assessment of ADMA, IMA, and Vitamin A and E Levels in Patients with Acne Vulgaris"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9339-8331","authenticated-orcid":false,"given":"Fatma","family":"Tun\u00e7ez Aky\u00fcrek","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Selcuk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gulcan","family":"Saylam Kurtipek","sequence":"additional","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Selcuk University Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huseyin","family":"Kurku","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Konya Education and Research Hospital Konya Turkey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fikret","family":"Akyurek","sequence":"additional","affiliation":[{"name":"Department of Biochemistry Faculty of Medicine Selcuk University Konya 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