{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,18]],"date-time":"2026-02-18T23:35:34Z","timestamp":1771457734107,"version":"3.50.1"},"reference-count":34,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,21]],"date-time":"2020-07-21T00:00:00Z","timestamp":1595289600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Acne is an inflammatory skin condition of pilosebaceous unit. Its pathogenesis is multifactorial with a central role of inflammatory and pro\u2010inflammatory cytokines mediators. Downregulated Kruppel\u2010like factor 2 (KLF2) leads to rapid secretion of many cytokines that are involved in acne pathogenesis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This study aimed at evaluating the level of KLF2 mRNA, clarifying its role in acne pathogenesis and its relation to acne lesion type, degree of severity, and outcome.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>The level of KLF2 mRNA was measured in 100 patients with acne and 50 age\u2010 and sex\u2010matched healthy controls by using quantitative real\u2010time polymerase chain reaction (qRT\u2010PCR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The value of KLF2 mRNA was lower in acne patients than control group (<jats:italic>P\u00a0&lt;\u00a0<\/jats:italic>.001), being lowest in inflammatory acne group (grades III, IV, and V) than noninflammatory acne group (grades I and II) and highest in the control group (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). KLF2 mRNA was decreased significantly with increased acne severity grade (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.001). KLF2 mRNA was lower in cases healed by scars than those healed by postinflammatory hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Decreased serum level of KLF2 is not only a claimed for AV pathogenesis but also a predictor for degree of acne severity and outcome.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13595","type":"journal-article","created":{"date-parts":[[2020,7,5]],"date-time":"2020-07-05T09:31:27Z","timestamp":1593941487000},"page":"964-970","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Role of KLF2: New insight in inflammatory acne pathogenesis"],"prefix":"10.1111","volume":"20","author":[{"given":"Menha A.","family":"Ibrahim","sequence":"first","affiliation":[{"name":"Dermatology, Venereology and Andrology Faculty of Medicine Benha University Benha Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shuzan 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