{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:57:42Z","timestamp":1790740662578,"version":"4.1.0"},"reference-count":7,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T00:00:00Z","timestamp":1595548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:sec><jats:title>Background<\/jats:title><jats:p>AA is an acquired dermatosis distributed universally, with multifactorial etiology. It affects the hair follicle with or without nail involvement, resulting in an acute nonscarring alopecia with a relapsing course.<jats:sup>1<\/jats:sup> Being a relatively common skin disease, LPP (lichen planopilaris) is initiated by a chronic lymphocytic inflammation that selectively destructs the hair follicles and eventually leads to scarring alopecia. Also, even though there is enough literature available for the co\u2010existence of AA and LPP with each other and their association with other autoimmune conditions, there are only very few reports on the anatomical concomitance of both disorders.<jats:sup>3<\/jats:sup><\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Although the incidence of not only one but two autoimmune diseases in an immunosuppressed individual is very unusual, we hereby report a case of co\u2010localization of AA and LPP in a patient receiving immunosuppression due to a previous history of SLE (Systemic lupus erythematosus).<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients<\/jats:title><jats:p>A 37\u2010year\u2010old woman, housewife, presented to our office with general alopecia on the scalp since about two years ago (Figure\u00a01), particularly on the vertex which was accompanied by mild itching and trichodynia. She had a history of hypothyroidism and lupus erythematosus arthritis. She had been receiving long\u2010term treatment with prednisolone, hydroxychloroquine, azathioprine, and levothyroxine but had not been treated for hair loss. Despite being on all of the above\u2010mentioned immunosuppressants, the patient developed AA and LPP which are both immune\u2010mediated diseases.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In addition to continuing her oral immunosuppressants, the patient was treated with Minoxidil 5% and Clobetasol solution as well as a higher dose of Azathioprine than she was receiving beforehand. Approximately, 3\u00a0months into the treatment, the follicular hyperkeratosis and scalp erythema resolved. Also, hair growth could be seen on AA spots.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our case report is indicating the possibly mutual immunopathogenesis of these two T cell\u2013mediated disorders. Furthermore, we want to bring attention to the probability of new autoimmune diseases occurring even during treatment with immunosuppressive medications.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13600","type":"journal-article","created":{"date-parts":[[2020,7,24]],"date-time":"2020-07-24T17:45:20Z","timestamp":1595612720000},"page":"976-979","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Co\u2010localization of alopecia areata and lichen planopilaris in a patient receiving immunosuppressants: A rare case"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5145-792X","authenticated-orcid":false,"given":"Ramin","family":"Mofarrah","sequence":"first","affiliation":[{"name":"Department of Dermatology Faculty of Medicine Islamic Azad University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramina","family":"Mofarrah","sequence":"additional","affiliation":[{"name":"Student Research Committee Shiraz University of Medical Sciences Shiraz Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3723-2521","authenticated-orcid":false,"given":"Kousar","family":"Jahani Amiri","sequence":"additional","affiliation":[{"name":"Student Research Committee Islamic Azad University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maryam","family":"Ghasemi","sequence":"additional","affiliation":[{"name":"Immunogenetics Research Center Faculty of Medicine Mazandaran University of Medical Sciences Sari Iran"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,7,24]]},"reference":[{"key":"e_1_2_5_2_1","unstructured":"CisternaM DiazM BovconML.Interdisiplinary treatment for areata alopecia: a twin case report. Academia Brasileira de Tricol.2014."},{"key":"e_1_2_5_3_1","doi-asserted-by":"publisher","DOI":"10.2147\/CCID.S137870"},{"key":"e_1_2_5_4_1","first-page":"45","article-title":"Co\u2010localization of alopecia areata and lichen planus: rare presentation","volume":"12","author":"Hassan I","year":"2014","journal-title":"NJDVL"},{"key":"e_1_2_5_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.41650"},{"key":"e_1_2_5_6_1","first-page":"242","article-title":"Colocalization of alopecia areata and lichen planus","volume":"70","author":"Kar BR","year":"2004","journal-title":"Indian J Dermatol Venereol Leprol"},{"key":"e_1_2_5_7_1","doi-asserted-by":"publisher","DOI":"10.1159\/000250627"},{"key":"e_1_2_5_8_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI551"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.wiley.com\/onlinelibrary\/tdm\/v1\/articles\/10.1111%2Fjocd.13600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13600","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13600","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13600","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,30]],"date-time":"2023-08-30T03:47:14Z","timestamp":1693367234000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13600"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,7,24]]},"references-count":7,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/jocd.13600"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13600","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,7,24]]},"assertion":[{"value":"2020-04-09","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-02","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-24","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}