{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T19:06:16Z","timestamp":1784919976509,"version":"3.55.0"},"reference-count":15,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Human hair follicles (HFs) express the olfactory receptor (OR)2AT4, which is selectively stimulated by the synthetic sandalwood\u2010like odorant, Sandalore<jats:sup>\u00ae<\/jats:sup>. In organ\u2010cultured, human scalp HFs, Sandalore<jats:sup>\u00ae<\/jats:sup> prolongs anagen and suppresses apoptosis by up\u2010regulating intrafollicular IGF\u20101 mediated signaling.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The objective of this study is to demonstrate whether effects of Sandalore<jats:sup>\u00ae<\/jats:sup> observed ex vivo translate into a clinically relevant effect in patients with telogen effluvium.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>In a randomized, double\u2010blinded, placebo\u2010controlled, clinical trial, 60 female volunteers (18\u201065\u00a0years) affected by telogen effluvium received over a period of 24\u00a0weeks treatment with either 1% Sandalore<jats:sup>\u00ae<\/jats:sup> solution (n\u00a0=\u00a030) or placebo (identically smelling, but non\u2010OR2AT4 activating sandalwood oil n\u00a0=\u00a030). The study read\u2010out parameters were the degree of hair shedding, hair volume, terminal\/vellus hair ratio, anagen\/catagen\u2010telogen ratio, and patient self\u2010assessment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Sandalore<jats:sup>\u00ae<\/jats:sup> 1% ameliorated clinical signs of telogen effluvium, namely it reduced hair shedding, and increased hair volume and the percentage of anagen HFs, the latter two parameters significantly more than placebo when changes were calculated to baseline. Sandalore<jats:sup>\u00ae<\/jats:sup> also increased the ratio of terminal\/vellus hairs at week 8. Most of the anti\u2010hair shedding effects were seen after 8\u00a0weeks and maintained at week 24. Patient questionnaire showed that verum group patients were more satisfied than the placebo group in regard to the overall results.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>This clinical trial supports previous findings of anagen\u2010prolonging effects of Sandalore<jats:sup>\u00ae<\/jats:sup> ex vivo with similar results now reproduced in clinical practice. It also provides proof\u2010of\u2010principle that a topically applied cosmetic odorant acting through HF olfactory receptors can be a therapeutic alternative to treat hair loss disorders characterized by excessive hair shedding such as telogen effluvium.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13608","type":"journal-article","created":{"date-parts":[[2020,7,9]],"date-time":"2020-07-09T20:59:30Z","timestamp":1594328370000},"page":"784-791","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Topical odorant application of the specific olfactory receptor OR2AT4 agonist, Sandalore<sup>\u00ae<\/sup>, improves telogen effluvium\u2010associated parameters"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1676-3056","authenticated-orcid":false,"given":"Francisco","family":"Jimenez","sequence":"first","affiliation":[{"name":"Mediteknia Clinic and Monasterium Clinical Hair Trial Unit Gran Canaria Spain"},{"name":"Universidad Fernando Pessoa Canarias Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3993-1385","authenticated-orcid":false,"given":"Esmeralda","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Mediteknia Clinic and Monasterium Clinical Hair Trial Unit Gran Canaria Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5927-6998","authenticated-orcid":false,"given":"Marta","family":"Bertolini","sequence":"additional","affiliation":[{"name":"Monasterium Laboratory, Skin and Hair Research Solutions GmbH Muenster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5783-6605","authenticated-orcid":false,"given":"Majid","family":"Alam","sequence":"additional","affiliation":[{"name":"Universidad Fernando Pessoa Canarias Gran Canaria Spain"},{"name":"Monasterium Laboratory, Skin and Hair Research Solutions GmbH Muenster Germany"},{"name":"Mediteknia Skin &amp; Hair Lab Gran Canaria Spain"},{"name":"Department of Dermatology and Venereology Qatar Translational Research Institute Hamad Medical Corporation Doha Qatar"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1901-0551","authenticated-orcid":false,"given":"J\u00e9r\u00e9my","family":"Ch\u00e9ret","sequence":"additional","affiliation":[{"name":"Monasterium Laboratory, Skin and Hair Research Solutions GmbH Muenster Germany"},{"name":"Dr. Phillip Frost Department of Dermatology &amp; Cutaneous Surgery University of Miami Miller School of Medicine Miami FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6645-9568","authenticated-orcid":false,"given":"Gill","family":"Westgate","sequence":"additional","affiliation":[{"name":"Gill Westgate Consultancy Ltd Stevington UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8645-1720","authenticated-orcid":false,"given":"Fabio","family":"Rinaldi","sequence":"additional","affiliation":[{"name":"Giuliani Pharma S.p.A Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2012-9149","authenticated-orcid":false,"given":"Barbara","family":"Marzani","sequence":"additional","affiliation":[{"name":"Giuliani Pharma S.p.A Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-9358","authenticated-orcid":false,"given":"Ralf","family":"Paus","sequence":"additional","affiliation":[{"name":"Monasterium Laboratory, Skin and Hair Research Solutions GmbH Muenster Germany"},{"name":"Dr. Phillip Frost Department of Dermatology &amp; 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