{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:24Z","timestamp":1787015544384,"version":"build-2736575974"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"Abstract<\/jats:title>\n \n Background<\/jats:title>\n \n Isobutylamido thiazolyl resorcinol (ITR, Thiamidol\n \u00ae<\/jats:sup>\n ) has been proposed as a potent tyrosinase inhibitor. A formulation containing ITR has recently shown promising efficacy for the treatment of some hyperpigmentary conditions.\n <\/jats:p>\n <\/jats:sec>\n \n Objectives<\/jats:title>\n This study aimed to evaluate the efficacy and safety of ITR in the prevention of ultraviolet (UV)\u2010induced hyperpigmentation in human skin.<\/jats:p>\n <\/jats:sec>\n \n Materials and Methods<\/jats:title>\n We performed a randomized, single\u2010blinded, pilot study in 30 healthy participants. One arm was randomly assigned to receive an ITR\u2010containing product for three weeks. Three hyperpigmented spots were induced by UVB irradiation on both arms after 3\u00a0weeks of ITR application. Outcome evaluations included measuring mean lightness index (*L) obtained by colorimeter, hyperpigmentation scores by visual analog scale (VAS), and adverse effects.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Both experimental sides showed no significant difference in terms of skin lightening after ITR application. However, the ITR\u2010treated sides showed a statistically significant lower mean lightness index compared to control after an induction with UVB. In addition, the ITR\u2010treated sides had an earlier improvement and resumed the normal skin color after 3\u00a0weeks post\u2010UVB induction. A clinical evaluation by a blinded nontreating physician and subjects was more favorable on the ITR\u2010treated side than the control side (\n P<\/jats:italic>\n \u00a0<\u00a0.05). No significant side effect was noted.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n ITR is an effective agent in the prevention of pigmentary change from UVB irradiation and may serve as a promising agent for preventing other hyperpigmentary conditions.<\/jats:p>\n <\/jats:sec>","DOI":"10.1111\/jocd.13615","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T09:27:06Z","timestamp":1596619626000},"page":"987-992","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":31,"title":["Isobutylamido thiazolyl resorcinol for prevention of UVB\u2010induced hyperpigmentation"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-939X","authenticated-orcid":false,"given":"Vasanop","family":"Vachiramon","sequence":"first","affiliation":[{"name":"Division of Dermatology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 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