{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:12:26Z","timestamp":1787015546988,"version":"build-2736575974"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T00:00:00Z","timestamp":1596585600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Various sebum levels can be detected in dandruff\u2010affected scalps. However, few studies have compared the biophysical characteristics of dandruff scalps categorized based on sebum levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Aims<\/jats:title>\n                    <jats:p>To investigate and compare the biophysical characteristics of dandruff\u2010affected scalps categorized based on sebum levels.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Fifty\u2010four Korean women with dandruff and 30 healthy Korean women underwent physiological measurements, including evaluation of sebum and hydration levels, pH, and transepidermal water loss (TEWL) in the scalp. The levels of the biomarkers of interleukin\u20108 (IL\u20108) and kallikrein 5 (KLK5) and corneodesmosomes were investigated in the stratum corneum (SC) of the scalp.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Dandruff was categorized as dry (low\u2010sebum, n\u00a0=\u00a025) or oily (high\u2010sebum, n\u00a0=\u00a029) based on a sebum cutoff level of 97.82\u00a0\u03bcg\/cm\n                      <jats:sup>2<\/jats:sup>\n                      . Both dry and oily dandruff\u2010affected scalps showed significantly decreased hydration levels and increased pH and TEWL compared with healthy subjects, with hydration levels being lower in dry dandruff\u2010affected scalps. IL\u20108 expression was significantly increased in the oily dandruff\u2010affected scalp. In addition, both dry and oily dandruff\u2010affected scalps showed significantly increased KLK5 levels in the SC, with the levels being higher in oily dandruff\u2010affected scalps. Altered distribution of corneodesmosomes, present on the entire surface area of the corneocytes, was notable in oily dandruff\u2010affected scalps.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The biophysical characteristics of the two types of dandruff represent the influence of different characteristics, including hydration levels, expression of IL\u20108 and KLK5, and corneodesmosome distribution. Thus, strategies to reduce dandruff levels should differ according to sebum levels.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.13626","type":"journal-article","created":{"date-parts":[[2020,8,5]],"date-time":"2020-08-05T09:15:29Z","timestamp":1596618929000},"page":"1002-1008","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":18,"title":["Biophysical characteristics of dandruff\u2010affected scalp categorized on the basis of sebum levels"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7354-3255","authenticated-orcid":false,"given":"Ji\u2010Seon","family":"Yoon","sequence":"first","affiliation":[{"name":"LG Household &amp; Health Care Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiyong","family":"Shim","sequence":"additional","affiliation":[{"name":"LG Household &amp; Health Care Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jun\u2010Man","family":"Lim","sequence":"additional","affiliation":[{"name":"LG Household &amp; Health Care Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sun Gyoo","family":"Park","sequence":"additional","affiliation":[{"name":"LG Household &amp; Health Care Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,5]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2230.1997.d01-231.x"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1382"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10119.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10104.x"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0846.2002.10320.x"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-002-0323-1"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-2494.2012.00723.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.4103\/0974-7753.82117"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-4632.2010.04629.x"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/bjd.13111"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00403-016-1681-4"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cosmetics2040384"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.1998.02457.x"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.2340\/00015555-1531"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1523-1747.2001.01321.x"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0625.2007.00562.x"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/JID.2015.363"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.jid.5700965"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20082242"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jid.2016.10.015"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13626","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13626","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13626","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,8,29]],"date-time":"2023-08-29T23:46:47Z","timestamp":1693352807000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13626"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,5]]},"references-count":20,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2021,3]]}},"alternative-id":["10.1111\/jocd.13626"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13626","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,5]]},"assertion":[{"value":"2020-04-20","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-08","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-05","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}