{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T16:30:20Z","timestamp":1784219420648,"version":"3.55.0"},"reference-count":22,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2020,7,29]],"date-time":"2020-07-29T00:00:00Z","timestamp":1595980800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,9]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Hypertrophic scars (HS) are a challenging disorder that mostly develops during wound\u2010healing process following skin injuries.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A split\u2010scar, double\u2010blind randomized controlled trial was held to assess the safety and efficacy of botulinum toxin type A (BTA) injection in hypertrophic scars (HS). Thirty patients with old scars (range: 1\u201015\u00a0years) were treated, with sides randomized to receive treatment with either BTA or 0.9% normal saline once monthly for three consecutive months. Scars were assessed using the Vancouver scar scale (VSS) along with digital photograph standardization.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010one subjects completed the study. The mean VSS score for the BTA\u2010treated half of the scars decreased from 7.29\u00a0\u00b1\u00a02.327 before injection to 5.33\u00a0\u00b1\u00a02.41 following injection which was highly significant (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.01). For the control half, the mean VSS decreased insignificantly from 7.29\u00a0\u00b1\u00a02.327 before injection to 7.10\u00a0\u00b1\u00a02.234 following injection (<jats:italic>P<\/jats:italic>\u00a0=\u00a0.104).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Clinical and cosmetic improvement was demonstrated significantly among the BTA\u2010treated group. BTA can be an additional and useful tool for improving scar outcomes.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13627","type":"journal-article","created":{"date-parts":[[2020,7,15]],"date-time":"2020-07-15T21:10:19Z","timestamp":1594847419000},"page":"2252-2258","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Effect of botulinum toxin type A for treating hypertrophic scars: A split\u2010scar, double\u2010blind randomized controlled trial"],"prefix":"10.1111","volume":"19","author":[{"given":"Ahmad R.","family":"Elshahed","sequence":"first","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Al Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaled S.","family":"Elmanzalawy","sequence":"additional","affiliation":[{"name":"Department of Dermatology, Venereology and Andrology Faculty of Medicine Al Azhar University Cairo 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