{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,3]],"date-time":"2026-10-03T01:11:03Z","timestamp":1790989863017,"version":"4.1.0"},"reference-count":27,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma is a common, multifactorial, and recurring disease which is not easy to treat.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>The purpose of this study is to evaluate the efficacy of microneedling in combination with Q\u2010switched neodymium\u2010doped yttrium aluminum garnet laser (QsNd\u2010YAG laser) for treatment of melasma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Fifteen female patients with epidermal or mixed\u2010type melasma on the face were included in the study. Patients were first treated with QsNd\u2010YAG laser, and then with microneedling containing mesotherapy products of biomimetic peptides, at the same session. Modified Melasma Area Severity Index (mMASI) scores were calculated before the first session and again 2\u00a0weeks after the last session. The same treatment protocol was repeated every 2\u00a0weeks for five sessions within period of 3\u00a0months of therapy. The evaluation was performed according to the before and after photographs taken from three angles including 90\u2010degree front and 45 degrees from left and right with the VISIA device.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Of the 15 patients included in the study, the mean mMASI scores before and after treatment were 9.2\u00a0\u00b1\u00a05.7 (3.8\u201023.1) and 3.6\u00a0\u00b1\u00a04.0 (0.6\u201016.8), respectively. mMASI scores were significantly reduced after completion of the protocol. Six (40%) patients had \u201cvery good response,\u201d 4 (26.7%) patients had \u201cgood response,\u201d and 5 (33.3%) patients were \u201cunresponsive.\u201d Six (40%) patients were followed up for 1\u00a0year, and only 1 patient had a recurrence (6.7%).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In addition to the use of photoprotective measures, multimodality treatment including QsNd\u2010YAG laser and microneedling with mesotherapy products containing biomimetic peptides is effective to treat melasma and they work synergistically.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13629","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T07:30:35Z","timestamp":1595403035000},"page":"769-775","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Efficacy of the combination of Q\u2010switched Nd:YAG laser and microneedling for 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