{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T15:35:51Z","timestamp":1781278551292,"version":"3.54.1"},"reference-count":6,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T00:00:00Z","timestamp":1598400000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,10]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Topical minoxidil is the only US FDA\u2010approved drug for the treatment of female pattern hair loss (FPHL). While the safety profile of topical minoxidil is excellent, the efficacy of minoxidil in hair growth is extremely low. A recent survey of 8000 people observed that only 4% of hair loss patients using an over\u2010the\u2010counter minoxidil were very satisfied with their results. In contrast, in clinical studies with an intervening physician, approximately 30%\u201040% of patients demonstrate an appreciable benefit. Compliance with topical drug regimens is often a major obstacle, limiting their effectiveness. Topical minoxidil leaves a greasy residue on the hair, which is especially problematic for women who do not wash their hair daily.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>We set out to develop an \u201cAfter Minoxidil\u201d companion spray to minoxidil that removes residual minoxidil from the hair, where it is not needed, yet leaves minoxidil on the scalp where it is required. We hypothesized that improving the cosmetic properties of minoxidil would improve patient compliance with the drug and subsequently improve clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cohort of 20 FPHL patients was recruited to use the novel \u201cAfter Minoxidil\u201d spray and report changes in hair quality on a Likert scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In our cohort of FPHL patients, the novel \u201cAfter Minoxidil\u201d spray restored ease of styling and reduced greasiness to preminoxidil level in 65% and 85% of subjects, respectively. The average reduction in perceived greasiness was 78%. Importantly, 70% of subjects interviewed stated they would likely continue to use the minoxidil and \u201cAfter Minoxidil\u201d treatment regimen for 6 months, vs 0% willing to use minoxidil alone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The novel \u201cAfter Minoxidil\u201d spray improved ease of hair styling and reduced greasiness following application of topical minoxidil; thus, the novel \u201cAfter Minoxidil\u201d spray may help improve drug compliance and efficacy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13630","type":"journal-article","created":{"date-parts":[[2020,8,26]],"date-time":"2020-08-26T19:26:23Z","timestamp":1598469983000},"page":"2647-2649","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Novel \u201cAfter Minoxidil\u201d spray improves topical minoxidil compliance and hair style manageability"],"prefix":"10.1111","volume":"19","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6579-5535","authenticated-orcid":false,"given":"Maja","family":"Kovacevic","sequence":"first","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital Center \u201cSestre milosrdnice\u201d Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1577-9910","authenticated-orcid":false,"given":"John","family":"McCoy","sequence":"additional","affiliation":[{"name":"Applied Biology Irvine CA USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerry","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Department of Dermatology New York University Langone Medical Center New York City NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodney","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Melbourne Melbourne Vic. Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Va\u00f1o\u2010Galvan","sequence":"additional","affiliation":[{"name":"Trichology Unit Dermatology Department Ramon y Cajal Hospital IRYCIS University of Alcala Madrid Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohamad","family":"Goldust","sequence":"additional","affiliation":[{"name":"University of Rome G. Marconi Rome Italy"},{"name":"Department of Dermatology University Hospital Basel Basel Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mirna","family":"Situm","sequence":"additional","affiliation":[{"name":"Department of Dermatology and Venereology University Hospital Center \u201cSestre Milosrdnice\u201d Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8190-2289","authenticated-orcid":false,"given":"Andy","family":"Goren","sequence":"additional","affiliation":[{"name":"Applied Biology Irvine CA USA"},{"name":"Department of Dermatology and Venereology Clinical Hospital Center Sestre Milosrdnice Zagreb Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,8,26]]},"reference":[{"key":"e_1_2_6_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1087-0024.2005.10102.x"},{"key":"e_1_2_6_3_1","unstructured":"US FDA Application 21\u2013812 Medical Review."},{"key":"e_1_2_6_4_1","volume-title":"Survey: Most Baldness Treatments Don't Work","author":"Mann D"},{"key":"e_1_2_6_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jaad.2007.04.012"},{"issue":"3","key":"e_1_2_6_6_1","first-page":"185","article-title":"Topical minoxidil: systematic review and meta\u2010analysis of its efficacy in androgenetic alopecia","volume":"13","author":"Gupta AK","year":"2015","journal-title":"Skinmed"},{"key":"e_1_2_6_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2016.10.016"}],"container-title":["Journal of Cosmetic Dermatology"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13630","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1111\/jocd.13630","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1111\/jocd.13630","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,3]],"date-time":"2023-09-03T07:15:23Z","timestamp":1693725323000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jocd.13630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,8,26]]},"references-count":6,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2020,10]]}},"alternative-id":["10.1111\/jocd.13630"],"URL":"https:\/\/doi.org\/10.1111\/jocd.13630","archive":["Portico"],"relation":{},"ISSN":["1473-2130","1473-2165"],"issn-type":[{"value":"1473-2130","type":"print"},{"value":"1473-2165","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,8,26]]},"assertion":[{"value":"2020-06-08","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-07-15","order":1,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2020-08-26","order":2,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}]}}