{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T16:34:46Z","timestamp":1783960486111,"version":"3.55.0"},"reference-count":20,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,7]],"date-time":"2020-08-07T00:00:00Z","timestamp":1596758400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Recent studies about the important roles of autophagy signaling in sebaceous lipogenesis and epidermal differentiation suggest potential benefits of autophagy activation in acne.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the effects of an autophagy activator on acne\u2010prone skin.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Autophagy signaling in human immortalized SZ95 sebocytes, normal human epidermal keratinocytes, and 3D reconstituted skin was examined. Effects of an autophagy\u2010activating peptide on sebaceous lipogenesis were measured by fluorescence microscopic analysis. The clinical efficacy in acne\u2010prone skin was evaluated through an eight\u2010week, double\u2010blind, randomized, vehicle\u2010controlled study. Changes in skin surface lipid compositions were further analyzed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In cultured sebocytes and keratinocytes, the investigated autophagy\u2010activating peptide increased LC3\u2010II expression, indicating a stimulation of autophagy signaling. Testosterone and linoleic acid treatment induced lipogenesis in cultured sebocytes and is further inhibited by the autophagy activator peptide treatment. Increased expression of differentiation marker proteins in cultured keratinocytes was also observed by autophagy\u2010activating peptide. In clinical study, reduction of closed comedones and the amount of skin surface lipids as well as of trans\u2010epidermal water loss (TEWL) were observed in acne\u2010prone skin after autophagy\u2010activating peptide application. In addition, reduction of squalene and increase in cholesterol were observed after an 8\u2010week application.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Topical application of an autophagy activator downregulated sebaceous lipogenesis and improved the skin barrier function. Considering the important roles of sebum and skin barrier function in acne pathogenesis, autophagy activation might represent a new therapeutic option in early forms of acne.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13636","type":"journal-article","created":{"date-parts":[[2020,7,22]],"date-time":"2020-07-22T20:24:42Z","timestamp":1595449482000},"page":"1009-1016","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":16,"title":["Topical application of autophagy\u2010activating peptide improved skin barrier function and reduced acne symptoms in acne\u2010prone skin"],"prefix":"10.1111","volume":"20","author":[{"given":"Yoonjin","family":"Lee","sequence":"first","affiliation":[{"name":"College of Life Science and Biotechnology Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kayoung","family":"Shin","sequence":"additional","affiliation":[{"name":"Research Division Incospharm Corp. Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyong\u2010Oh","family":"Shin","sequence":"additional","affiliation":[{"name":"Department of Food Science and Nutrition Hallym University Chuncheon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6282-2219","authenticated-orcid":false,"given":"Seokjeong","family":"Yoon","sequence":"additional","affiliation":[{"name":"Research Division Incospharm Corp. Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juyeon","family":"Jung","sequence":"additional","affiliation":[{"name":"Research Division Incospharm Corp. Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eojin","family":"Hwang","sequence":"additional","affiliation":[{"name":"Research Division Incospharm Corp. 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Daejeon South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amir M.","family":"Hossini","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Venereology, Allergology and Immunology Dessau Medical Center Brandenburg Medical School Theodor Fontane Dessau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1646-2608","authenticated-orcid":false,"given":"Christos C.","family":"Zouboulis","sequence":"additional","affiliation":[{"name":"Departments of Dermatology, Venereology, Allergology and Immunology Dessau Medical Center Brandenburg Medical School Theodor Fontane Dessau Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8696-389X","authenticated-orcid":false,"given":"Min Jeong","family":"Baek","sequence":"additional","affiliation":[{"name":"Dermapro Skin Research Center DERMAPRO Ltd. Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6326-843X","authenticated-orcid":false,"given":"Ji Hwoon","family":"Baek","sequence":"additional","affiliation":[{"name":"Dermapro Skin Research Center DERMAPRO Ltd. Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young Min","family":"Chi","sequence":"additional","affiliation":[{"name":"College of Life Science and Biotechnology Korea University Seoul South Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4720-9955","authenticated-orcid":false,"given":"Sangeun","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Dermatology Yonsei University College of Medicine Gangnam Severance Hospital Seoul Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9201-0227","authenticated-orcid":false,"given":"Sekyoo","family":"Jeong","sequence":"additional","affiliation":[{"name":"Research Division Incospharm Corp. 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