{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T01:13:47Z","timestamp":1787015627552,"version":"build-2736575974"},"reference-count":13,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T00:00:00Z","timestamp":1597104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"funder":[{"DOI":"10.13039\/501100013314","name":"Higher Education Discipline Innovation Project","doi-asserted-by":"publisher","award":["D18011"],"award-info":[{"award-number":["D18011"]}],"id":[{"id":"10.13039\/501100013314","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Infraorbital dark circles (DC) are defined as a symptom that presents darkness under infraorbital eyelids. The objective of this study was to evaluate the efficacy and safety of nano\u2010microneedle\u2010assisted phenylethyl resorcinol (PR) for the treatment of infraorbital dark circles.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Twenty female participants were randomized to two groups. In the experimental group (group E), participants received topical PR gel under the left orbit once a day and topical plus nano\u2010microneedle\u2010assisted PR gel under the right orbit twice a week. In the control group (group C), participants were treated with gel without PR. Melanin index (MI) and erythema index (EI) were measured before the session (T0), 4 and 8\u00a0weeks during the treatment session (T4, T8), and 1 and 2\u00a0months after the last session (T12, T16). The global assessment was performed by a blinded dermatologist.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The mean value of MI in group E was significantly lower than the baseline at T8 (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05), and the right side decreased more significantly than the left side (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&lt;\u00a0.05). However, there was no difference of MI before and after treatment in group C (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). There was no big difference of the mean EI between the two sides (\n                      <jats:italic>P<\/jats:italic>\n                      \u00a0&gt;\u00a0.05). The treatment was well tolerated, and no serious adverse effects were reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PR combined with nano\u2010microneedle could be an effective and safe method for infraorbital DC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1111\/jocd.13641","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T01:51:43Z","timestamp":1597197103000},"page":"884-889","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Clinical efficacy and safety of nano\u2010microneedle\u2010assisted phenylethyl resorcinol for the treatment of infraorbital dark circles"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4676-5426","authenticated-orcid":false,"given":"Cheng\u2010Qian","family":"Yu","sequence":"first","affiliation":[{"name":"Department of Dermatology No. 1 Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xue\u2010Gang","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Dermatology No. 1 Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong\u2010Duo","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Dermatology No. 1 Hospital of China Medical University  Shenyang China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuan\u2010Hong","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Dermatology No. 1 Hospital of China Medical University  Shenyang 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