{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,29]],"date-time":"2026-07-29T06:11:15Z","timestamp":1785305475721,"version":"3.55.0"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,6]],"date-time":"2020-09-06T00:00:00Z","timestamp":1599350400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Although being a benign lesion, xanthelasma palpebrarum (XP) causes cosmetic concerns. There are numerous therapeutic methods for XP with adverse events for each method.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>Evaluate the safety, efficacy, and downtime of fractional CO<jats:sub>2<\/jats:sub> laser (10\u00a0600\u00a0nm) versus 50% trichloroacetic acid (TCA) in XP therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Comparative interventional prospective study involved 20 adult patients with XP. Each patient received a split\u2010face therapy where xanthelasma lesions treated with fractional CO<jats:sub>2<\/jats:sub> laser on the one side and TCA 50% on the other side for maximum 5 sessions with 2\u2010week intervals in between.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Statistically significant improvement in lesion color, thickness, and size by both fractional CO<jats:sub>2<\/jats:sub> and TCA 50%, with nonstatistically significant difference between both therapeutic modalities after treatment, although downtime, number of sessions, and patient's satisfaction were significantly better for fractional CO<jats:sub>2<\/jats:sub> laser.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Fractional CO<jats:sub>2<\/jats:sub> laser (10\u00a0600\u00a0nm) is ideal for treatment of xanthelasma because it is safe and effective with short downtime, more patient satisfaction, less sessions, and less complications compared with chemical peeling using TCA (50%).<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13666","type":"journal-article","created":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T16:00:14Z","timestamp":1596988814000},"page":"763-768","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Fractional CO<sub>2<\/sub> laser versus trichloroacetic acid 50% for xanthelasma palpebrarum therapy"],"prefix":"10.1111","volume":"20","author":[{"given":"Nissreen Al\u2010Sayed","family":"Al\u2010Kady","sequence":"first","affiliation":[{"name":"Dermatology and Venereology Department Faculty of Medicine (for Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2575-8566","authenticated-orcid":false,"given":"Mervat","family":"Hamdino","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department Faculty of Medicine (for Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Faten Abdel wadoud","family":"Abdel Kawy","sequence":"additional","affiliation":[{"name":"Dermatology and Venereology Department Faculty of Medicine (for Girls) Al\u2010Azhar University Cairo Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,6]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02913335"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12137"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006534-200210000-00016"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/SCS.0000000000003830"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1096-9101(1999)24:2<122::AID-LSM7>3.0.CO;2-6"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/lsm.1117"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2133.2007.08194.x"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/jocd.12148"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1097\/DSS.0000000000000186"},{"key":"e_1_2_7_11_1","first-page":"149","article-title":"Treatment of xanthelasma palpebrarum by fractional carbon dioxide laser. 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