{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T19:08:30Z","timestamp":1771268910076,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,11,28]],"date-time":"2020-11-28T00:00:00Z","timestamp":1606521600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The plant species <jats:italic>Anemarrhena asphodeloides<\/jats:italic> has commonly been used for health and therapeutic purposes. Timosaponin B\u2010II, which is present at a high concentration in <jats:italic>A\u00a0asphodeloides<\/jats:italic>, was found to enhance the immune and anti\u2010inflammatory responses of human bodies.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate benefits of a timosaponin B\u2010II containing scalp care solution on hair loss prevention and scalp healthiness in multiple physiological and biological profiles.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Prior the study, 90 subjects applied scalp care solution base without timosaponin B\u2010II for two weeks followed by application of the scalp care solution containing 0.5% timosaponin B\u2010II for 28\u00a0days. The subject's hair follicle hydrocortisone level, hair fall number, hair luster level, dandruff level, sensation score, hydration level, lipid level, redness as well as the pH level of scalps were quantitatively assessed every 7\u00a0days.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Multiple parameters on hair and scalp conditions were promoted by application of the timosaponin B\u2010II containing scalp care solution. Compared to baseline values, significant improvements in hair luster, scalp hydration, hair fall number, and scalp redness level could be observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Timosaponin B\u2010II promotes multiple physiological factors on hair and scalps. The scalp care solution containing <jats:italic>A\u00a0asphodeloides<\/jats:italic> extracts may benefit the scalp healthiness and hair loss prevention.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13672","type":"journal-article","created":{"date-parts":[[2020,8,12]],"date-time":"2020-08-12T03:39:11Z","timestamp":1597203551000},"page":"819-824","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["A Timosaponin B\u2010II containing scalp care solution for improvement of scalp hydration, dandruff reduction, and hair loss prevention: A comparative study on healthy volunteers before and after application"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3638-4486","authenticated-orcid":false,"given":"Lei","family":"Xiao","sequence":"first","affiliation":[{"name":"School of Food Science and Engineering Guangdong Province Key Laboratory for Green Processing of Natural Products and Product Safety South China University of Technology  Guangzhou China"},{"name":"Infinitus (China) Co.  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