{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,14]],"date-time":"2026-10-14T05:13:31Z","timestamp":1791954811501,"version":"4.3.4"},"reference-count":16,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2020,9,21]],"date-time":"2020-09-21T00:00:00Z","timestamp":1600646400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,3]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Injective procedures using polynucleotides\u2010based products to promote dermal rejuvenation and revitalization are steadily evolving, yet no structured protocols are available that discuss and provide guidance in aesthetic treatments with highly purified polynucleotides. The goal of this document was to provide consensus\u2010based recommendations for the safe and effective use of Polynucleotides Highly Purified Technology\u2122 (PN\u2010HPT\u2122) devices for skin rejuvenation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>A team of eight experts with extensive experience in treatments for skin rejuvenation and revitalization integrated the best available evidence and clinical judgment and devised a series of practical guidance to support dermatologists, plastic surgeons, and aesthetic physician in the use of PN\u2010HPT\u2122 products, alone and in combination, in aesthetic medicine.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>For most items, the expert group achieved a majority consensus. \u201cRecommendations\u201d (consensus &gt;80%) were reached for the face, periocular area, d\u00e9collet\u00e9 and neck, hands, scalp, and stretch marks. Recommendations include details of techniques, information on dosage, volumes to be injected, and the ideal number of required treatment sessions, as well as time intervals between them for different areas of face and body. A lower agreement level of 60% was reached on but one item related to the initial treatment cycle for the face, leading to a \u201cConsensus statement\u201d for that area instead of a full \u201cRecommendation.\u201d<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The expert consensus illustrates the value of natural\u2010origin, highly purified polynucleotides (PN\u2010HPT\u2122) as biostimulatory booster strategy for skin priming and revitalization of face and body and provides a detailed guide for the use.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13679","type":"journal-article","created":{"date-parts":[[2020,8,16]],"date-time":"2020-08-16T09:14:10Z","timestamp":1597569250000},"page":"922-928","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":67,"title":["Consensus report on the use of PN\u2010HPT\u2122 (polynucleotides highly purified technology) in aesthetic medicine"],"prefix":"10.1111","volume":"20","author":[{"given":"Maurizio","family":"Cavallini","sequence":"first","affiliation":[{"name":"Operative Unit of Dermatologic and Plastic Surgery CDI Hospital  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuele","family":"Bartoletti","sequence":"additional","affiliation":[{"name":"Director, Esthetic Medicine Outpatients Service Fatebenefratelli Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Maioli","sequence":"additional","affiliation":[{"name":"Maioli Private Practice Sassari  Sassari Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alberto","family":"Massirone","sequence":"additional","affiliation":[{"name":"Agor\u00e0 President, Italian Scientific Society of Aesthetic Medicine  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabella","family":"Pia Palmieri","sequence":"additional","affiliation":[{"name":"Contract Professor, Esthetic Medicine Master, \u201cFederico II\u201d University Medical School  Naples Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Papagni","sequence":"additional","affiliation":[{"name":"Member of the Board Agor\u00e0 Italian Scientific Society of Aesthetic Medicine  Milan Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maurizio","family":"Priori","sequence":"additional","affiliation":[{"name":"President, SIES, Esthetic Medicine and Surgery Society  Florence Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria","family":"Trocchi","sequence":"additional","affiliation":[{"name":"Vice\u2010President, SIMES Italian Society of Esthetic Medicine Fatebenefratelli Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"As Members of The Polynucleotides HPT\u2122 Priming Board, Collegio Italiano delle Societ\u00e0 Scientifiche di Medicina Estetica (Italian College of the Aesthetic Medicine Scientific Societies) \u2014 SIME, AGOR\u00c0, SIES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,9,21]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/dth.12299"},{"key":"e_1_2_10_3_1","first-page":"30","article-title":"A polynucleotide\u2010based product to treat female hormonal hair loss","author":"Gianfaldoni R","year":"2014","journal-title":"Prime"},{"key":"e_1_2_10_4_1","first-page":"102","article-title":"Tightening upper arms skin laxity with intradermal polynucleotides gel biorevitalization","volume":"40","author":"D\u2019Aloiso MC","year":"2016","journal-title":"LME\u2010La Medicina Estetica"},{"key":"e_1_2_10_5_1","first-page":"3","article-title":"Long\u2010chain polynucleotides gel and skin biorevitalization","volume":"3","author":"Cavallini 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