{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:28:00Z","timestamp":1783351680642,"version":"3.54.6"},"reference-count":21,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T00:00:00Z","timestamp":1603670400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aim<\/jats:title><jats:p>To evaluate the effectiveness of treating mimetic facial lines with an incobotulinumtoxinA (INCO) and Cohesive Polydensified Matrix<jats:sup>\u00ae<\/jats:sup> hyaluronic acid (CPM\u2010HA) combination.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Subjects with moderate\u2010to\u2010severe lateral periorbital lines (LPL) and perioral lines at rest according to Merz Aesthetics Scales<jats:sup>\u2122<\/jats:sup> received 10\u00a0U of INCO\/eye and up to 10\u00a0U to the perioral area. This was followed by intradermal injection of 1\u20103\u00a0cc CPM\u2010HA to the same lines. Primary outcomes were physician\u2010 and subject\u2010rated improvement at 1\u00a0month using the Global Aesthetic Improvement Scale (GAIS) and changes in line severity using the Merz Aesthetics Scales<jats:sup>\u2122<\/jats:sup>.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study included 10 women aged 42\u201074\u00a0years with moderate\u2010to\u2010severe LPL and perioral lines at baseline. At 1\u00a0month, treating physician GAIS scores indicated 45.0% of subjects were very much improved and 52.5% much improved; 75% remained at least improved at 6\u00a0months. Subject GAIS results indicated 7 women rated themselves as very much improved and 3 as much improved. For LPL, improvements of \u22651\u2010point on the Merz Aesthetics Scales<jats:sup>\u2122<\/jats:sup> compared with baseline were seen at 1, 3, and 6\u00a0months in 86.8%, 74.3%, and 65.8% of subjects, respectively. For perioral lines, improvements of \u22651\u2010point were observed for 89.2%, 86.5%, and 73.0% at 1, 3, and 6\u00a0months, respectively. No treatment\u2010related adverse events were observed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Combined INCO\/CPM\u2010HA filler in individuals with moderate\u2010to\u2010severe LPL and perioral lines was effective at improving overall appearance and reducing line severity in two highly mobile facial areas that are the first to show lines of aging.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13745","type":"journal-article","created":{"date-parts":[[2020,10,14]],"date-time":"2020-10-14T06:33:01Z","timestamp":1602657181000},"page":"1459-1466","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Evaluating an incobotulinumtoxinA and Cohesive Polydensified Matrix<sup>\u00ae<\/sup> hyaluronic acid filler combination to treat moderate\u2010to\u2010severe periorbital and perioral rhytids"],"prefix":"10.1111","volume":"20","author":[{"given":"Sheila C.","family":"Barbarino","sequence":"first","affiliation":[{"name":"Barbarino Surgical Arts Austin TX USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julie A.","family":"Woodward","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology and Department of Dermatology Duke University Medical Center Durham NC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer","family":"Levine","sequence":"additional","affiliation":[{"name":"Lenox Hill Hospital Manhattan Eye Ear and Throat Hospital New York NY USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Fezza","sequence":"additional","affiliation":[{"name":"Center for Sight Sarasota FL USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,26]]},"reference":[{"key":"e_1_2_8_2_1","unstructured":"American Society for Aesthetic Plastic Surgery.Cosmetic (Aesthetic) Surgery National Data Bank statistics.2018. 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