{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,6]],"date-time":"2026-05-06T15:37:27Z","timestamp":1778081847108,"version":"3.51.4"},"reference-count":32,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,16]],"date-time":"2020-10-16T00:00:00Z","timestamp":1602806400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The potential efficacy of vascular component\u2010targeted laser has been evaluated for the treatment of melasma, which commonly found with the co\u2010existence of telangiectasia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the treatment efficacy and safety of 585\u2010nm QSNYL and 4% HQ cream combination vs 4% HQ cream alone for telangiectatic melasma in the skin phototypes III\u2010V.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Twenty\u2010one Thai female patients with telangiectatic melasma and Fitzpatrick skin phototypes (FPTs) III\u2010V were randomly treated with the 585\u2010nm QSNYL on one side of the face for five sessions at 2\u2010week intervals. All patients were assigned to apply HQ cream daily at night on both sides of the face for 10 weeks and a broad\u2010spectrum sunscreen regularly throughout the study. The treatment efficacy and safety were evaluated using the Modified Melasma Area and Severity Index (mMASI), biometric evaluation, patient assessment, and adverse effects.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The combination\u2010treated side yielded more significant improvement of mMASI than the topical\u2010treated side at weeks 2, 4, and 8, respectively. However, 19% of the patients developed postinflammatory hyperpigmentation (PIH) on the laser\u2010treated side, especially in FPTs IV\u2010V and rebound hyperpigmentation. There was a significant improvement of hemoglobin and melanin index, but without statistical difference between the two treatment groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>The combination of 585\u2010nm QSNYL and HQ treatment yields treatment efficacy and skin rejuvenation effects for telangiectatic melasma. Nonetheless, a high incidence of PIH and rebound hyperpigmentation is adversely developed in dark FPT. Thus, this laser treatment should be cautiously applied in those with dark FPTs IV\u2010V to avoid laser\u2010induced pigment alteration.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13756","type":"journal-article","created":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T17:18:06Z","timestamp":1601572686000},"page":"1700-1708","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Postinflammatory and rebound hyperpigmentation as a complication after treatment efficacy of telangiectatic melasma with 585 nanometers Q\u2010switched Nd: YAG laser and 4% hydroquinone cream in skin phototypes III\u2010V"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8121-2982","authenticated-orcid":false,"given":"Suparuj","family":"Lueangarun","sequence":"first","affiliation":[{"name":"Division of Dermatology Chulabhorn International College of Medicine, Thammasat University Pathumthani 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