{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T03:57:51Z","timestamp":1790740671188,"version":"4.1.0"},"reference-count":56,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,19]],"date-time":"2020-10-19T00:00:00Z","timestamp":1603065600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Cancers are one of the main reasons of morbidity and mortality globally. Chemotherapy\u2010induced alopecia (CIA) is one of the most alarming, terrifying, and traumatic adverse effects. A range of therapeutic measures has been suggested to alleviate CIA, but at present, there is no accepted pharmacological therapy that can assure prevention or management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>The aim of the present study was to evaluate the efficacy of QR 678 Neo\u00ae therapy in the treatment of persistent chemotherapy\u2010induced alopecia in women and men treated with cytotoxic chemotherapy for breast and lung cancers, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 8 male patients with history of lung cancer and 12 female patients with history of breast cancer in the age range of 25\u201060\u00a0years, with WHO classification of grade I and II persistent alopecia who had undergone chemotherapy treatment, were selected for the study. At each visit, 1.5\u00a0mL solution of QR 678<jats:sup>\u00ae<\/jats:sup> was injected into the scalp skin of patients. A total of 8 sessions were performed at an interval of 3\u00a0weeks each. All the patients were evaluated with standard global photography, video microscopic assessment, and patient self\u2010assessment questionnaire at baseline, 6\u00a0months, and 1\u00a0year.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Marked improvement was seen in the global assessment score at 6 months (mean\u20108) which was maintained even after 1\u00a0year. Mean score increase in hair count at 6\u00a0months was 12.71 which further increased at 1\u00a0year. High satisfaction score was given by patients for slowing of hair loss (mean\u00a0=\u00a04.2) and also for overall hair growth. For appearance and growth of hair, the mean value was 3.4 and 3.8, respectively.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The formulation of QR 678<jats:sup>\u00ae<\/jats:sup> and QR 678<jats:sup>\u00ae<\/jats:sup> Neo showed to be significantly safe and efficient for chemotherapy\u2010induced alopecia in both men and women. Improvement in hair growth was maintained even at 1\u00a0year of follow\u2010up. No patient had any severe adverse effects, and injections were also easily bearable by most of them.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13759","type":"journal-article","created":{"date-parts":[[2020,10,5]],"date-time":"2020-10-05T10:09:39Z","timestamp":1601892579000},"page":"3270-3279","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Evaluation of efficacy of QR678<sup>\u00ae<\/sup> and QR678<sup>\u00ae<\/sup> Neo hair growth factor formulation in the treatment of persistent chemotherapy\u2010induced alopecia caused due to cytotoxic chemotherapy\u2014A prospective pilot study"],"prefix":"10.1111","volume":"19","author":[{"given":"Rinky","family":"Kapoor","sequence":"first","affiliation":[{"name":"Department of Dermatology Cosmetic Dermatology &amp; Dermato\u2010Surgery &amp; Director The Esthetic Clinics  Mumbai India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2163-1170","authenticated-orcid":false,"given":"Debraj","family":"Shome","sequence":"additional","affiliation":[{"name":"Department of Facial Plastic Surgery &amp; 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