{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T00:19:01Z","timestamp":1786925941993,"version":"build-2736575974"},"reference-count":60,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2020,10,27]],"date-time":"2020-10-27T00:00:00Z","timestamp":1603756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Proton\u2010pump inhibitors (PPIs) are one of the most prescribed drugs. Their dermatological adverse reactions are multiple and vary in severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>This review discusses all reported cutaneous side effects of PPIs in order to help physicians understand them and provide appropriate management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A thorough search of PubMed, Embase, and FDAAQ8 drugs websites was conducted. 56 articles including case reports, case series, and review articles of PPI\u2010induced cutaneous adverse reactions were selected. Data were recorded regarding patient age, gender, history, clinical manifestations, diagnostic tests, management, and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>PPI\u2010induced adverse skin reactions are mostly immunological and include both immediate and delayed\u2010type hypersensitivity reactions. These reactions are sometimes life\u2010threatening. All PPIs can induce immediate IgE\u2010mediated reactions. Most of previously published cases of delayed\u2010type hypersensitivity reactions have involved esomeprazole, omeprazole, and lansoprazole. Skin tests are helpful in confirming PPI\u2010induced hypersensitivity reactions and diagnosing potential cross\u2010reactivities. PPIs should also be added to our list of usual suspects when considering possible culprits for a new presentation of drug\u2010induced subacute lupus erythematosus. PPI\u2010related occupational contact dermatitis has also been numerously reported.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>PPIs should be considered in our list of culprits when considering a patient with a cutaneous drug reaction, taking into account that these drugs can cause severe immunological manifestations.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13763","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T18:43:55Z","timestamp":1602182635000},"page":"1073-1079","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Dermatologic adverse reactions to proton\u2010pump inhibitors: A synthetized review"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7184-9859","authenticated-orcid":false,"given":"Antoine","family":"Salloum","sequence":"first","affiliation":[{"name":"Department of Dermatology Saint Georges 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