{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T01:32:59Z","timestamp":1747186379424,"version":"3.40.5"},"reference-count":33,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,20]],"date-time":"2020-10-20T00:00:00Z","timestamp":1603152000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Vitiligo is an acquired depigmentation of the skin and the mucous membranes, exhibited as white macules and patches due to selective loss of melanocytes. Etiological theories of vitiligo include genetic, immunological, neurohormonal, cytotoxic, biochemical, oxidative stress, and newer theories of melanocytorrhagy and diminished melanocytes survival. It has been revealed that liver X receptor alpha gene is expressed in skin tissue such as sebaceous glands, hair follicle, keratinocytes, and fibroblasts and is linked to various skin disorders as acne vulgaris and psoriasis.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim of the Study<\/jats:title><jats:p>To evaluate the association between liver X receptor\u2010\u03b1 gene polymorphism (rs11039155 and rs2279238) and vitiligo and whether they are related to disease activity and severity or not.<\/jats:p><\/jats:sec><jats:sec><jats:title>Subjects and Methods<\/jats:title><jats:p>50 vitiligo patients and 20 age\u2010 and sex\u2010matched apparently healthy controls were enrolled. All the included subjects were genotyped using polymerase chain reaction\u2010restriction fragment length polymorphism analysis technique for (\u22126G\/A) and (+1257C\/T) SNPs.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Significant statistical difference between cases and controls regarding genotype and allele frequencies for \u22126G\/A polymorphism with predominance of AA genotype (OR: 5.1, 95% CI: 1.6\u201015.9) and A allele (OR: 5.3, 95% CI: 1.6\u201015.9) in cases and also for +1257C\/T polymorphism with predominance of TT genotype OR: 9.2 (95% CI: 1.4\u201082.9) and T allele OR: 3.4 (95% CI: 1.4\u20108.1) in vitiligo cases. No significant relationship between \u22126G\/A genotypes nor +1257C\/T genotypes and disease activity and severity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The study showed significant association between Liver X receptor gene polymorphisms (\u22126G\/A, +1257 C\/T) and development of vitiligo in Egyptian patients. However, it failed to show any relation with disease activity nor severity.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13772","type":"journal-article","created":{"date-parts":[[2020,10,8]],"date-time":"2020-10-08T18:47:11Z","timestamp":1602182831000},"page":"1906-1914","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Genetic polymorphism of liver X receptor gene in vitiligo: Does it have an association?"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7126-8261","authenticated-orcid":false,"given":"Wafaa A.","family":"Shehata","sequence":"first","affiliation":[{"name":"Dermatology, Andrology and STDs Department Menoufia University Shebin El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alaa","family":"Maraee","sequence":"additional","affiliation":[{"name":"Dermatology, Andrology and STDs Department Menoufia University Shebin El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marwa","family":"Mehesin","sequence":"additional","affiliation":[{"name":"General Practitioner in Health Sector Shebin El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nermin","family":"Tayel","sequence":"additional","affiliation":[{"name":"Lecturer of Molecular Diagnostics &amp; Therapeutics Molecular Diagnostics &amp; Therapeutics Department Genetic Engineering and Biotechnology Research Institute Sadat City University Sadat Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rania","family":"Azmy","sequence":"additional","affiliation":[{"name":"Medical Biochemistry and Molecular Biology Department Menoufia University Shebin El\u2010Kom Egypt"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2020,10,20]]},"reference":[{"key":"e_1_2_8_2_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-148X.2012.00997.x"},{"key":"e_1_2_8_3_1","doi-asserted-by":"publisher","DOI":"10.3109\/08916930108994127"},{"key":"e_1_2_8_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2014.65"},{"key":"e_1_2_8_5_1","doi-asserted-by":"publisher","DOI":"10.4103\/0019-5154.26928"},{"key":"e_1_2_8_6_1","doi-asserted-by":"publisher","DOI":"10.1034\/j.1600-0749.2003.00067.x"},{"key":"e_1_2_8_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/skinbio.2011.7"},{"key":"e_1_2_8_8_1","doi-asserted-by":"publisher","DOI":"10.2337\/diabetes.53.2007.S36"},{"key":"e_1_2_8_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.26951"},{"key":"e_1_2_8_10_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.0022-202x.2001.01628.x"},{"key":"e_1_2_8_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ijo.0803705"},{"key":"e_1_2_8_12_1","doi-asserted-by":"publisher","DOI":"10.1097\/FPC.0b013e3283452fec"},{"key":"e_1_2_8_13_1","doi-asserted-by":"publisher","DOI":"10.1017\/S0007114507201722"},{"key":"e_1_2_8_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/jid.2012.409"},{"key":"e_1_2_8_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(14)60763-7"},{"key":"e_1_2_8_16_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp0804388"},{"key":"e_1_2_8_17_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/750342"},{"key":"e_1_2_8_18_1","doi-asserted-by":"publisher","DOI":"10.4103\/0378-6323.26722"},{"key":"e_1_2_8_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.mgene.2016.02.001"},{"key":"e_1_2_8_20_1","doi-asserted-by":"publisher","DOI":"10.2165\/00128071-200102030-00006"},{"key":"e_1_2_8_21_1","doi-asserted-by":"publisher","DOI":"10.12998\/wjcc.v3.i3.221"},{"key":"e_1_2_8_22_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1468-3083.2007.02228.x"},{"key":"e_1_2_8_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/BF02254984"},{"key":"e_1_2_8_24_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0749.2006.00333.x"},{"key":"e_1_2_8_25_1","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2133.2003.05024.x"},{"key":"e_1_2_8_26_1","doi-asserted-by":"publisher","DOI":"10.5021\/ad.2012.24.2.115"},{"key":"e_1_2_8_27_1","first-page":"760","article-title":"Liver X receptors (LXRs). 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