{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,8]],"date-time":"2026-04-08T16:59:27Z","timestamp":1775667567855,"version":"3.50.1"},"reference-count":25,"publisher":"Wiley","issue":"12","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2020,12]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Melasma is a chronic pigmentary condition that can have significant negative effects on quality of life. Vitamin C can be effective in the treatment melasma, but its delivery often proves to be challenging due to instability of the drug and subsequent cutaneous irritation at higher concentrations.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>In this prospective, open\u2010label, evaluator\u2010blinded study, we aimed to assess the efficacy and tolerability of twice\u2010daily application of a novel, highly potent, non\u2010irritating 30% tetrahexyldecyl (THD) ascorbate serum in combination with 100% mineral\u2010based sunscreen in the treatment of melasma during the summer months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients\/Methods<\/jats:title><jats:p>Ten female subjects of ages ranging from 18 to 60\u00a0years underwent twice\u2010daily application of 30% THD ascorbate serum in combination with an anti\u2010aging 100% mineral tinted broad\u2010spectrum protection SPF 45 sunscreen moisturizer for 12\u00a0weeks during the summer months (July to September). Two blinded evaluators scored baseline and post\u2010treatment photographs using the Griffiths\u2019 10\u2010point scale and global aesthetic improvement scale.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>All subjects showed an improvement in hyperpigmentation with an average improvement of 33.7%. Seventy percent of subjects showed an improvement in skin tone evenness (redness), and among those subjects, the average improvement was 33.3%. The median global aesthetic improvement score was 2.0 (very much improved).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Our study demonstrated efficacy and safety in treating the pigmentary as well as vascular components of melasma with a novel 30% THD ascorbate serum and a purely mineral\u2010based tinted moisturizing sunscreen.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13787","type":"journal-article","created":{"date-parts":[[2020,10,15]],"date-time":"2020-10-15T19:19:11Z","timestamp":1602789551000},"page":"3251-3257","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Effective lightening of facial melasma during the summer with a dual regimen: A prospective, open\u2010label, evaluator\u2010blinded study"],"prefix":"10.1111","volume":"19","author":[{"given":"Ryan C.","family":"Kelm","sequence":"first","affiliation":[{"name":"Department of Dermatology Rush University Chicago IL 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