{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,10]],"date-time":"2026-07-10T16:04:48Z","timestamp":1783699488072,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T00:00:00Z","timestamp":1603929600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Isobutylamido thiazolyl resorcinol (ITR) is a novel anti\u2010tyrosinase recently shown to be effective in the treatment of hyperpigmentation. Low\u2010fluence Q\u2010switched Nd:YAG 1064\u2010nm laser (LFQS) has proven to be effective for various hyperpigmentary conditions. However, there is no study on the efficacy and safety of combined ITR and LFQS treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>To compare the efficacy and safety of combined ITR and LFQS with LFQS monotherapy for facial hyperpigmentation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>Patients with symmetrical facial hyperpigmentation were treated with five sessions of once weekly LFQS on the whole face. One side was randomly treated with ITR and the other side received a placebo cream for 12\u00a0weeks. Patients were followed for 8\u00a0weeks after the last laser treatment. Relative lightness index (RL*I), Facial Hyperpigmentation Severity Score on the malar area (FHSS<jats:sub>m<\/jats:sub>), patient satisfaction, recurrence, and adverse events were recorded.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Twenty\u2010four patients completed the study. Both sides demonstrated significant reductions of mean RL*I and mean FHSS<jats:sub>m<\/jats:sub> from baseline (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.01). At the 4th week, the ITR\u2010treated side showed more improvement of mean RL*I than the placebo\u2010treated side (62.5% vs 47.3% improvement, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The mean FHSS<jats:sub>m<\/jats:sub> on the ITR\u2010treated was reduced at a significantly higher percentage than the placebo\u2010treated side (54.4% vs 40.2% reduction, <jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). Partial recurrence was observed on both sides. No serious side effects were noted.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Combined ITR and LFQS therapy was more superior than LFQS monotherapy in the treatment of facial hyperpigmentation. ITR may serve as adjuvant for patients with such condition.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13790","type":"journal-article","created":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T10:18:49Z","timestamp":1603966729000},"page":"1724-1731","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Combined isobutylamido thiazolyl resorcinol and low\u2010fluence Q\u2010switched Nd: YAG laser for the treatment of facial hyperpigmentation: A randomized, split\u2010face study"],"prefix":"10.1111","volume":"20","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7328-939X","authenticated-orcid":false,"given":"Vasanop","family":"Vachiramon","sequence":"first","affiliation":[{"name":"Division of Dermatology Faculty of Medicine Ramathibodi Hospital Mahidol University Bangkok 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