{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T16:52:36Z","timestamp":1790959956304,"version":"4.1.0"},"reference-count":19,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T00:00:00Z","timestamp":1604102400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/onlinelibrary.wiley.com\/termsAndConditions#vor"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["J of Cosmetic Dermatology"],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Laser therapies have brought dawn to refractory skin diseases, but also were accompanied by postlaser inflammation and skin barrier dysfunction. To recover skin function quickly, the research and development of active ingredients including \u03b2\u2010glucan for postlaser repair have attracted much attention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aims<\/jats:title><jats:p>To evaluate the efficacy and tolerance of skin care regimens containing \u03b2\u2010glucan (Dermdoc\u00ae;Songyang Biotech) in repairing postlaser inflammation and skin barrier dysfunction after fractional laser therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A total of 20 patients with facial atrophic acne scars who accepted fractional laser therapy were recruited: 10 patients treated with ablative fractional CO2 laser and 10 patients treated with 1565nm nonablative fractional laser. Using the method of split\u2010face vehicle\u2010control study, the left half of the face was served as the treatment side and accepted skin care regimens, and the right half was control side accepted vehicle. Noninvasive bioinstrumentation of skin hydration index, transepidermal water loss (TEWL), and hemoglobin index (E value) was detected in the study. Standard digital photographs were taken at each visit. The skin tolerance and adverse effect were also evaluated by subject questionnaire.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Compared with the control side, the Hemoglobin index (E value) of the treatment side was improved more significantly on the 7th day (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05). The skin hydration index of the treatment side was better than that of the control side on the 7th and 14th day (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).\u00a0After treatment, the TEWL of the treatment side on the 7th day was statistically significantly lower than that of the control side (<jats:italic>P<\/jats:italic>\u00a0&lt;\u00a0.05).\u00a0In the subject self\u2010assessment questionnaires, 63.2% thought the repair effect of \u03b2\u2010glucan regimens was better than that of vehicle. The skin care regimens were well tolerated without obvious side reactions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The skin care regimens containing \u03b2\u2010glucan may play a positive role in accelerating the recovery of skin inflammation and barrier function after fractional laser therapy.<\/jats:p><\/jats:sec>","DOI":"10.1111\/jocd.13798","type":"journal-article","created":{"date-parts":[[2020,10,31]],"date-time":"2020-10-31T12:44:58Z","timestamp":1604148298000},"page":"1756-1762","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":19,"title":["Administration of skin care regimens containing \u03b2\u2010glucan for skin recovery after fractional laser therapy: A split\u2010face, double\u2010blinded, vehicle\u2010controlled 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Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiyan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine Shanghai Skin Disease Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuli","family":"Wang","sequence":"additional","affiliation":[{"name":"Institute of Photomedicine Shanghai Skin Disease Hospital Tongji University School of Medicine Shanghai China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2020,10,31]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pdpdt.2017.06.010"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.5978\/islsm.14-RE-01"},{"issue":"6","key":"e_1_2_9_4_1","first-page":"51","article-title":"Nonablative Fractional Laser Resurfacing in Skin of 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